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Optical isomerism and chiral centres: OCR A‑Level Chemistry A questions

OCR A-Level Chemistry A past-paper questions on 6.2.2.2 Optical isomerism and chiral centres, 2016–2025, with mark schemes and examiner’s reports where available.

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  2. Q2(c)(ii)

    June 2024 · Paper 3

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  3. Q21(a)

    June 2023 · Paper 2

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  4. Q21(b)(ii)

    June 2023 · Paper 2

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  5. Q21(c)(i)

    June 2023 · Paper 2

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  7. Q5

    June 2022 · Paper 2

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  8. Q16(b)(iv)

    June 2022 · Paper 2

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  10. Q6(a)

    June 2022 · Paper 3

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  12. Q18(a)(i)

    November 2021 · Paper 2

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  13. Q18(a)(ii)

    November 2021 · Paper 2

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  14. Q18(a)(iii)

    November 2021 · Paper 2

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  15. Q16(b)(i)

    November 2020 · Paper 2

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  16. Q16(b)(ii)

    November 2020 · Paper 2

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  17. Q7

    June 2019 · Paper 2

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  19. Q4(b)(i)

    June 2019 · Paper 3

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All 23 questions on Optical isomerism and chiral centres, as a list
  1. June 2025, Paper 2, Q10 (1 mark): How many stereoisomers does the compound CH3CH(Br)CH=CHCH(Cl )CH3 have? A 2 B 4 C 6 D 8 Your answer [1]
  2. June 2024, Paper 3, Q2(c)(ii) (1 mark): How many chiral carbon atoms are there in one molecule of compound B? [1]
  3. June 2023, Paper 2, Q21(a) (1 mark): The general formula of an α-amino acid is RCH(NH2)COOH. Most α-amino acids show optical isomerism. Explain the term optical isomerism. [1]
  4. June 2023, Paper 2, Q21(b)(ii) (2 marks): Draw diagrams to show 3D structures of the optical isomers of valine. [2]
  5. June 2023, Paper 2, Q21(c)(i) (1 mark): How many optical isomers are possible for compound E? [1]
  6. June 2023, Paper 3, Q3 (6 marks): 3* A chemist is investigating compound A, shown below, as a potential organic intermediate. O OH CN Compound A Describe the type of stereoisomerism shown by com
  7. June 2022, Paper 2, Q5 (1 mark): The structure of a drug is shown below: O OH HO HO F O How many chiral carbon atoms are there in a molecule of the drug? A 5 B 6 C 7 D 8 Your answer [1]
  8. June 2022, Paper 2, Q16(b)(iv) (2 marks): Draw 3D structures for the optical isomers of compound C. Optical isomers [2]
  9. June 2022, Paper 2, Q17 (6 marks): This question is about an analysis of an unknown organic Compound X. Some properties of Compound X are shown in the table. Molecular formula Functional groups C
  10. June 2022, Paper 3, Q6(a) (1 mark): The structure of vitamin C is shown below. Vitamin C is an optical isomer. O O H H H O O O O H Vitamin C What is the total number of optical isomers with the st
  11. November 2021, Paper 2, Q2 (1 mark): Which type(s) of stereoisomerism is/are shown by 2,4-dimethylhex-2-ene? A E / Z isomerism only. B Optical isomerism only. C Both E / Z isomerism and optical iso
  12. November 2021, Paper 2, Q18(a)(i) (1 mark): Explain the term optical isomerism. [1]
  13. November 2021, Paper 2, Q18(a)(ii) (2 marks): Draw 3-D diagrams to show the optical isomers of alanine. [2]
  14. November 2021, Paper 2, Q18(a)(iii) (1 mark): How many optical isomers does threonine have? [1]
  15. November 2020, Paper 2, Q16(b)(i) (1 mark): Explain the term stereoisomers and name this type of stereoisomerism. Explanation: Type of stereoisomerism: [1]
  16. November 2020, Paper 2, Q16(b)(ii) (2 marks): Draw 3D diagrams for the stereoisomers of (CH3)3CCHBrCH3. [2]
  17. June 2019, Paper 2, Q7 (1 mark): What is the number of chiral carbon atoms in the steroid molecule below? OH O A 5 B 6 C 7 D 8 Your answer [1]
  18. June 2019, Paper 2, Q16(b)(v) (4 marks): The structures of geraniol and citronellal are repeated below with the carbon atoms numbered. 1 1 7 7 5 4 3 5 3 2 4 8 OH 8 2 6 O 6 Geraniol Citronellal Explain
  19. June 2019, Paper 3, Q4(b)(i) (1 mark): α-Terpineol is a chiral compound. Show with an asterisk, (*), the chiral centre(s) in the structure of α-terpineol. OH α-terpineol [1]
  20. June 2018, Paper 2, Q11 (1 mark): How many straight-chain structural isomers of C7H15Cl contain a chiral carbon atom? A 1 B 2 C 3 D 4 Your answer [1]
  21. June 2018, Paper 2, Q17(a) (2 marks): The α-amino acid cysteine (R = CH2SH) shows optical isomerism. Draw 3-D diagrams to show the optical isomers of cysteine. [2]
  22. June 2017, Paper 2, Q8 (1 mark): What is the number of chiral centres in the molecule below? NH2 H N S O N HO O OH O A 2 B 3 C 4 D 5 Your answer [1]
  23. June 2017, Paper 3, Q4(a)(ii) (6 marks): The structure of compound A is shown below. O HO OH R compound A Compound A has four optical isomers. Using this information and the student’s results, answer t

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