plumiGene therapy: OCR A‑Level Biology A questions
OCR A-Level Biology A past-paper questions on 6.1.3.4 Gene therapy, 2016–2025, with mark schemes and examiner’s reports where available.
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Q6(b)
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All 8 questions on Gene therapy, as a list
- June 2025, Paper 3, Q6(b) (6 marks): β‑thalassemia is an inherited blood disorder in which the β‑globin chain of haemoglobin is changed or absent in a person’s red blood cells. Many different DNA m
- June 2022, Paper 3, Q1(d)(i) (2 marks): Suggest how using gene therapy to increase levels of the AC6 gene in heart cells may improve heart function. [2]
- June 2022, Paper 3, Q1(d)(ii) (1 mark): State one method for inserting the AC6 gene into the heart cells during gene therapy. [1]
- June 2022, Paper 3, Q1(d)(iii) (1 mark): The results from gene therapy trials are published in peer-reviewed journals. State why the results from gene therapy trials are published in journals. [1]
- June 2019, Paper 2, Q17(b)(i) (3 marks): The treatment of cystic fibrosis is described as somatic gene therapy. Another type of gene therapy is known as germ-line gene therapy. Complete the table below
- June 2019, Paper 2, Q17(b)(ii) (2 marks): Some attempts at gene therapy have resulted in changes to the functioning of other genes. Explain how inserting a new gene into a chromosome could affect the fu
- June 2019, Paper 2, Q17(b)(iii) (1 mark): CF occurs when individuals have two copies of a recessive allele. Huntington’s disease is a lethal disease caused by a dominant allele that codes for the protei
- June 2017, Paper 2, Q12 (1 mark): Which of the following statements about gene therapy is not correct? A changes resulting from gene therapy cannot be passed on to offspring B germ-line gene the
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