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Biological molecules: OCR A‑Level Biology A questions

Every OCR A-Level Biology A exam question on 2.1.2 Biological molecules, 2016–2025, with its mark scheme and examiner’s report.

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1,984 questions

  1. Q1

    June 2025 · Paper 1

    The whole paper ↗
    June 2025 Paper 1, question 1: Which option describes a function of inorganic ions? Ca2+ is pumped across the membrane of a neurone to establish the resting potential. A Cl– and HCO3 – are in
  2. Q2

    June 2025 · Paper 1

    The whole paper ↗
    June 2025 Paper 1, question 2: Which option describes a conjugated protein? A A globular protein with a prosthetic group B A protein with an inorganic ion C A protein with more than one polyp
  3. Q4

    June 2025 · Paper 1

    The whole paper ↗
    June 2025 Paper 1, question 4: Which option describes the structure of biological molecules? A Carbohydrates contain only C, H and O, usually with an H to O ratio of 2 : 1. B Nucleic acids co
  4. Q1

    June 2025 · Paper 2

    The whole paper ↗
    June 2025 Paper 2, question 1: Hydrogen bonds are important for the physical and chemical properties of water. How do hydrogen bonds form in water? Electronegative (δ–) oxygen atoms are attra
  5. Q2

    June 2025 · Paper 2

    The whole paper ↗
    June 2025 Paper 2, question 2: Water has many properties that are important for living organisms. Which property of water molecules explains why small animals, such as pond skaters, are able
  6. Q4

    June 2025 · AS Paper 1

    The whole paper ↗
    June 2025 AS Paper 1, question 4: A student carries out a non-reducing sugar test on a sample of fruit juice. What is the correct reason for heating the sample with hydrochloric acid? A It break
  7. Q5

    June 2025 · AS Paper 1

    The whole paper ↗
    June 2025 AS Paper 1, question 5: A student is finding out the concentration of a sample of protein. • They set up five solutions that have a range of different protein concentrations. • They ca
  8. Q9

    June 2025 · AS Paper 1

    The whole paper ↗
    June 2025 AS Paper 1, question 9: Which row of the table correctly compares the properties of glycogen and amylose? Glycogen Amylose A Branched Branched B Insoluble Soluble C Insoluble Insoluble
  9. Q1(a)

    June 2025 · AS Paper 2

    The whole paper ↗
    June 2025 AS Paper 2, question 1(a): The table describes features of molecules. Complete the table. Use ticks (3) to identify if the feature describes starch or cellulose. Description Starch Cellul
  10. Q1(b)

    June 2025 · AS Paper 2

    The whole paper ↗
    June 2025 AS Paper 2, question 1(b): Students complete paper chromatography on carbohydrates. The table shows the Rf values for known carbohydrates. © researchgate.net, ResearchGate. Item removed d
  11. Q1(c)

    June 2025 · AS Paper 2

    The whole paper ↗
    June 2025 AS Paper 2, question 1(c): Outline the role of the solvent in paper chromatography. [2]
  12. Q1

    June 2024 · Paper 1

    The whole paper ↗
    June 2024 Paper 1, question 1: Which statement about lipids is correct? A Lipids are polar molecules. B Lipids that contain fatty acids with carbon–carbon double bonds are liquid at room temp
  13. Q2

    June 2024 · Paper 1

    The whole paper ↗
    June 2024 Paper 1, question 2: Lipids, polysaccharides, nucleic acids and proteins are all macromolecules. Which statement about macromolecules is correct? A All macromolecules are formed in
  14. Q16(a)

    June 2024 · Paper 1

    The whole paper ↗
    June 2024 Paper 1, question 16(a): The table lists some biological molecules. Complete the table by putting a tick (✓) in the appropriate box or boxes on each line to show whether the correspondi
  15. Q16(b)

    June 2024 · Paper 1

    The whole paper ↗
    June 2024 Paper 1, question 16(b): Describe the bond between the two glucose monomers in maltose. [2]
  16. Q16(c)(i)

    June 2024 · Paper 1

    The whole paper ↗
    June 2024 Paper 1, question 16(c)(i): Complete the equation for the conversion of maltotriose to glucose. CH2OH CH2OH CH2OH CH2OH O O O O H H H H H H H H H + 3 OH H OH H OH H OH H HO OH HO OH O O H
  17. Q5(d)

    June 2024 · Paper 3

    The whole paper ↗
    June 2024 Paper 3, question 5(d): The table lists statements about a molecule of insulin. Complete the table by stating the level of protein structure (primary, secondary, tertiary or quaternary
  18. Q9

    June 2024 · AS Paper 1

    The whole paper ↗
    June 2024 AS Paper 1, question 9: Lactose is a carbohydrate. Which feature describes the structure of lactose? A Lactose contains glycosidic bonds that are broken by a condensation reaction B La
  19. Q10

    June 2024 · AS Paper 1

    The whole paper ↗
    June 2024 AS Paper 1, question 10: The diagram shows a triglyceride molecule found in sunflower oil. O O O O O O Which option describes the structure of this triglyceride molecule? A Contains pho
  20. Q24(a)(i)

    June 2024 · AS Paper 1

    The whole paper ↗
    June 2024 AS Paper 1, question 24(a)(i): In addition to having a quaternary structure, haemoglobin also has primary, secondary and tertiary structures. The table below contains statements about the str
All 172 questions on Biological molecules, as a list
  1. June 2025, Paper 1, Q1 (1 mark): Which option describes a function of inorganic ions? Ca2+ is pumped across the membrane of a neurone to establish the resting potential. A Cl– and HCO3 – are in
  2. June 2025, Paper 1, Q2 (1 mark): Which option describes a conjugated protein? A A globular protein with a prosthetic group B A protein with an inorganic ion C A protein with more than one polyp
  3. June 2025, Paper 1, Q4 (1 mark): Which option describes the structure of biological molecules? A Carbohydrates contain only C, H and O, usually with an H to O ratio of 2 : 1. B Nucleic acids co
  4. June 2025, Paper 2, Q1 (1 mark): Hydrogen bonds are important for the physical and chemical properties of water. How do hydrogen bonds form in water? Electronegative (δ–) oxygen atoms are attra
  5. June 2025, Paper 2, Q2 (1 mark): Water has many properties that are important for living organisms. Which property of water molecules explains why small animals, such as pond skaters, are able
  6. June 2025, AS Paper 1, Q4 (1 mark): A student carries out a non-reducing sugar test on a sample of fruit juice. What is the correct reason for heating the sample with hydrochloric acid? A It break
  7. June 2025, AS Paper 1, Q5 (1 mark): A student is finding out the concentration of a sample of protein. • They set up five solutions that have a range of different protein concentrations. • They ca
  8. June 2025, AS Paper 1, Q9 (1 mark): Which row of the table correctly compares the properties of glycogen and amylose? Glycogen Amylose A Branched Branched B Insoluble Soluble C Insoluble Insoluble
  9. June 2025, AS Paper 2, Q1(a) (3 marks): The table describes features of molecules. Complete the table. Use ticks (3) to identify if the feature describes starch or cellulose. Description Starch Cellul
  10. June 2025, AS Paper 2, Q1(b) (2 marks): Students complete paper chromatography on carbohydrates. The table shows the Rf values for known carbohydrates. © researchgate.net, ResearchGate. Item removed d
  11. June 2025, AS Paper 2, Q1(c) (2 marks): Outline the role of the solvent in paper chromatography. [2]
  12. June 2024, Paper 1, Q1 (1 mark): Which statement about lipids is correct? A Lipids are polar molecules. B Lipids that contain fatty acids with carbon–carbon double bonds are liquid at room temp
  13. June 2024, Paper 1, Q2 (1 mark): Lipids, polysaccharides, nucleic acids and proteins are all macromolecules. Which statement about macromolecules is correct? A All macromolecules are formed in
  14. June 2024, Paper 1, Q16(a) (3 marks): The table lists some biological molecules. Complete the table by putting a tick (✓) in the appropriate box or boxes on each line to show whether the correspondi
  15. June 2024, Paper 1, Q16(b) (2 marks): Describe the bond between the two glucose monomers in maltose. [2]
  16. June 2024, Paper 1, Q16(c)(i) (2 marks): Complete the equation for the conversion of maltotriose to glucose. CH2OH CH2OH CH2OH CH2OH O O O O H H H H H H H H H + 3 OH H OH H OH H OH H HO OH HO OH O O H
  17. June 2024, Paper 3, Q5(d) (2 marks): The table lists statements about a molecule of insulin. Complete the table by stating the level of protein structure (primary, secondary, tertiary or quaternary
  18. June 2024, AS Paper 1, Q9 (1 mark): Lactose is a carbohydrate. Which feature describes the structure of lactose? A Lactose contains glycosidic bonds that are broken by a condensation reaction B La
  19. June 2024, AS Paper 1, Q10 (1 mark): The diagram shows a triglyceride molecule found in sunflower oil. O O O O O O Which option describes the structure of this triglyceride molecule? A Contains pho
  20. June 2024, AS Paper 1, Q24(a)(i) (3 marks): In addition to having a quaternary structure, haemoglobin also has primary, secondary and tertiary structures. The table below contains statements about the str
  21. June 2024, AS Paper 2, Q6(a)(i) (2 marks): The general structure of an amino acid molecule has one R group and two other groups. Name the two other groups in an amino acid molecule. 1 2 [2]
  22. June 2024, AS Paper 2, Q6(a)(ii) (1 mark): Below is a diagram of a dipeptide. R1 O H R2 H O N C C N C C H O H H H Draw a circle around the peptide bond. Answer on the diagram. [1]
  23. June 2024, AS Paper 2, Q6(a)(iii) (1 mark): Name the type of reaction involved in breaking the peptide bond. [1]
  24. June 2024, AS Paper 2, Q6(b) (2 marks): Which statements about biological molecules are true and which are false? Tick (✓) one box in each row. Statement True False Breaking one ester bond in a trigly
  25. June 2023, Paper 1, Q1 (1 mark): Which description of biological molecules is correct? A DNA and RNA are both polymers of nucleotides. B Hydrolysis of sucrose produces fructose and β-glucose. C
  26. June 2023, Paper 1, Q2 (1 mark): Which statement about lipids is correct? A Phospholipids are formed by esterification of glycerol with three molecules of fatty acid. B Phospholipids containing
  27. June 2023, Paper 1, Q3 (1 mark): Which statement about the structure of amino acids is not true? A Amino acids contain amino and carboxyl groups. B Amino acids contain the elements hydrogen, ca
  28. June 2023, Paper 1, Q4 (1 mark): Which of the options is a feature of collagen? A It allows alveoli to recoil B It dissolves in water C It is flexible D It is the main protein found in hair You
  29. June 2023, Paper 2, Q10 (1 mark): Which of the molecules contains the highest proportion of 1-6 glycosidic bonds? A Amylopectin B Amylose C Cellulose D Glycogen Your answer [1]
  30. June 2023, Paper 2, Q11 (1 mark): Which of the molecules is not used for energy storage? A Amylopectin B Amylose C Cellulose D Glycogen Your answer [1]
  31. June 2023, Paper 2, Q21(c)(i) (3 marks): Write on the diagram to show the complete structure of alpha glucose. [3]
  32. June 2023, Paper 2, Q21(c)(ii) (2 marks): Explain how the structure of glucose allows it to move from the plant to the bacterium. [2]
  33. June 2023, Paper 3, Q2(a)(i) (1 mark): Most vitamins are colourless. Suggest one method for visualising the vitamins in TLC. [1]
  34. June 2023, Paper 3, Q2(a)(ii) (2 marks): The results of the TLC are shown in the chromatogram in Fig. 2.1. Fig. 2.1 Solvent front Vitamin B6 Vitamin B1 Vitamin B2 Vitamin C Origin Use Fig. 2.1 to calcu
  35. June 2023, AS Paper 1, Q11 (1 mark): Which statement is a correct description of polymers? A A polymer is broken down by condensation reactions. B A polymer is formed when two monomers bond togethe
  36. June 2023, AS Paper 1, Q12 (1 mark): A scientist analysed and recorded all of the chemical elements in one particular amino acid. Which elements did the scientist record? A C, H, N, S B C, H, O, N
  37. June 2023, AS Paper 1, Q13 (1 mark): Which description of the structure of a glucose molecule is correct? A It contains 5 OH groups and has a C:O ratio of 1:1. B It contains 6 OH groups and has a C
  38. June 2023, AS Paper 1, Q14 (1 mark): Which description of the structure of cellulose is correct? A Alternate α-glucose monomers rotate 180° B Branched polymer forms from β-glucose monomers C Hydrog
  39. June 2023, AS Paper 1, Q23(a) (1 mark): Name and describe the reaction that produces amino acids from polypeptides. [1]
  40. June 2023, AS Paper 1, Q23(b)(i) (2 marks): Use the chromatogram to calculate the Rf value of valine. Rf = [2]
  41. June 2023, AS Paper 1, Q23(b)(ii) (1 mark): Serine and leucine have different R groups. With reference to the chromatogram, suggest what can be concluded about the chemical properties of the R groups in s
  42. June 2023, AS Paper 1, Q28(b) (4 marks): Starch and glycogen are polysaccharides. Starch is present in plant cells, and glycogen is present in animal cells. Glucose is a monosaccharide present in both
  43. June 2023, AS Paper 2, Q3(a)(i) (1 mark): The above test would not detect the presence of protein in the sample. State the change that needs to be made to this test to enable protein to be detected. [1]
  44. June 2023, AS Paper 2, Q3(a)(ii) (2 marks): Sodium hydroxide is a white solid ionic compound which is highly soluble in water. It consists of anions and cations. Complete the table below. State the chemic
  45. June 2023, AS Paper 2, Q3(b) (6 marks): (b)* The students were provided with another sample of an unknown liquid. They carried out chemical tests on this sample to determine what biological molecules
  46. June 2023, AS Paper 2, Q3(c)(i) (3 marks): The students were then asked to carry out an experiment to determine the glucose concentration of another test solution using a colorimeter. Describe how the st
  47. June 2023, AS Paper 2, Q3(c)(ii) (2 marks): The students plotted their results, shown in the graph. 80 70 60 50 40 Absorption (%) 30 20 10 0 0 0.001 0.002 0.003 0.004 0.005 0.006 Glucose concentration (mm
  48. June 2023, AS Paper 2, Q5(b)(ii) (2 marks): Collagen is a protein found in ligaments. Ligaments attach bone to bone and stabilise joints. State the properties of collagen that make it suitable for this fu
  49. June 2022, Paper 1, Q1 (1 mark): Which statement describes the properties or functions of cholesterol? A It increases the fluidity of the phospholipid bilayer at high temperatures. B It is an u
  50. June 2022, Paper 1, Q2 (1 mark): Which statement describes triglycerides? A They are broken down by condensation reactions. B They are polymers of glycerol and fatty acids. C They contain ester
  51. June 2022, Paper 1, Q17 (6 marks): 17* The thermal properties of water allow organisms to live in an environment with relatively small changes in temperature. These properties also make water eff
  52. June 2022, Paper 2, Q8 (1 mark): Which statement about the secondary structure of a protein is correct? A β-pleated sheets contain β-glucose. B Disulfide bonds are not involved. C Each single p
  53. June 2022, Paper 2, Q9 (1 mark): Cellulose is the main component of plant cell walls. Which option is not a property of cellulose? A High tensile strength B Inflexible C Insoluble in water D Re
  54. June 2022, Paper 2, Q10 (1 mark): Glycogen is a large polysaccharide. Which option describes the structure and function of glycogen? A 1–6 glycosidic bonds are more accessible to enzymes than 1–
  55. June 2022, Paper 2, Q16(a)(i) (1 mark): Name the bond present in the primary structure of a protein. [1]
  56. June 2022, Paper 2, Q16(a)(ii) (1 mark): Name the structure labelled X. [1]
  57. June 2022, Paper 2, Q16(a)(iii) (1 mark): State one feature, visible in Fig. 16.1, that shows that haemoglobin is a globular protein. [1]
  58. June 2022, Paper 2, Q21(b)(ii) (2 marks): Both bacteria also break down some of the protein casein, which is present in milk. Name the product of protein breakdown and describe the type of reaction that
  59. June 2022, Paper 2, Q21(d)(i) (4 marks): A colorimeter can be used, along with biuret reagent, to determine the concentration of protein in a solution. Outline how to use a colorimeter to determine the
  60. June 2022, Paper 2, Q21(d)(ii) (1 mark): State one alternative method for determining the concentration of protein in a solution. [1]
  61. June 2022, AS Paper 1, Q4 (1 mark): The table shows the chemical symbols for some inorganic ions involved in biological processes. Ammonium ion Calcium ion Nitrate ion + Ca+ – A NH4 NO2 – Ca2+ – B
  62. June 2022, AS Paper 1, Q20 (1 mark): An enzyme hydrolyses a phospholipid molecule to release a fatty acid. What is the name of the bond that is broken in this hydrolysis reaction? A Ester B Glycosi
  63. June 2022, AS Paper 1, Q21(a) (3 marks): The amino acid cysteine is abbreviated to ‘CYS’ in Fig. 21.1. The side chain (R group) found in cysteine is shown in Fig. 21.2. Complete Fig. 21.2 to show the s
  64. June 2022, AS Paper 1, Q21(b) (2 marks): Explain how Fig. 21.1 shows that insulin has a quaternary structure. [2]
  65. June 2022, AS Paper 1, Q21(c)(i) (1 mark): Suggest why insulin glargine is long-lasting. [1] 14 The table shows some of the DNA triplet codes for amino acids. 1st base 2nd base of DNA triplet 3rd base of
  66. June 2022, AS Paper 1, Q25(a)(i) (3 marks): Draw two water molecules and label the bond between the two molecules. [3]
  67. June 2022, AS Paper 1, Q25(a)(ii) (3 marks): Explain how the properties of water are related to the transport role of water in a stem. [3]
  68. June 2022, AS Paper 2, Q3(a)(i) (2 marks): Name the type of bond broken by the enzyme lactase and describe what happens when this bond is broken. [2]
  69. June 2022, AS Paper 2, Q3(b)(i) (1 mark): Describe how the structure of a polyunsaturated triglyceride molecule would differ from the molecule shown in Fig. 3.2. [1]
  70. June 2022, AS Paper 2, Q3(b)(ii) (3 marks): Hypercholesterolemia is a condition in which an individual has a high blood cholesterol level. Studies were carried out in the USA over several decades, looking
  71. November 2021, Paper 2, Q1 (1 mark): Which of the options is a function of fibrous proteins? A aids rigidity of membranes B involved in cell signalling C provides elasticity in alveoli D speeds up
  72. November 2021, Paper 2, Q2 (1 mark): Which of the types of molecule is shown in the diagram? H H O N C C H OH CH2 CH2 CH2 CH2 NH2 A amino acid B fatty acid C nitrogenous base D nucleotide [1] Your
  73. November 2021, Paper 3, Q3(a) (2 marks): Callose is formed from β-glucose monomers. The figure below shows a section of callose. OH O CH2OH HO O O carbon 1 CH2OH CH2OH CH2OH CH2OH CH2OH O O O O O HO HO
  74. November 2021, Paper 3, Q4(a) (2 marks): Some organisms use a disaccharide called trehalose as a respiratory substrate. Trehalose has a similar structure and very similar chemical properties to sucrose
  75. November 2021, Paper 3, Q5(a) (1 mark): Amylose is formed from the glucose molecules produced in photosynthesis. Table 5.1 shows three statements about amylose, which may be true or false. Complete Ta
  76. November 2021, AS Paper 1, Q8 (1 mark): The molecule below is the disaccharide sucrose. CH2OH CH2OH O O H H H H OH H H OH O CH2OH HO H OH OH H Which row, A to D, shows the type of reaction that occurs
  77. November 2021, AS Paper 1, Q9 (1 mark): Sucrase is the enzyme that breaks down sucrose. Which of the bonds, A to D, is broken by sucrase? A alpha glycosidic B beta glycosidic C ester D peptide Your an
  78. November 2021, AS Paper 1, Q20 (1 mark): A student carried out four tests on samples from a beaker of starch and amylase. Which row, A to D, would show the correct results if the reaction was still hap
  79. November 2021, AS Paper 2, Q1(a)(i) (1 mark): State one property of glucose that allows it to be easily transported in animals. [1]
  80. November 2021, AS Paper 2, Q1(a)(ii) (3 marks): Explain how the structure of glycogen differs from that of amylopectin to make it better suited as an energy store in animals. [3]
  81. November 2021, AS Paper 2, Q1(a)(iii) (1 mark): Fig. 1.1 shows the molecular structure of beta glucose. CH2OH O H OH H OH H HO H H OH Fig. 1.1 Describe how the structure of alpha glucose would be different fr
  82. November 2021, AS Paper 2, Q1(b) (1 mark): Fig. 1.2 shows the start of the ring structure of ribose. Complete the diagram to show the position of the carbon atoms. There is no need to include the –H and
  83. November 2020, Paper 2, Q10 (1 mark): Which of the following reactions, A to D, describes the conversion of a polymer to a monomer? esterification fatty acids and glycerol → triglyceride A condensat
  84. November 2020, Paper 2, Q20(b)(i) (3 marks): In plants the glucose produced by photosynthesis is changed into starch for storage. Glucose and starch are both carbohydrates. ()Ctamplete the table below to s
  85. November 2020, Paper 2, Q20(b)(ii) (1 mark): Carbohydrates contain only the elements carbon, hydrogen and oxygen. Polypeptides contain carbon, hydrogen, oxygen and nitrogen. Name one other element present
  86. November 2020, Paper 3, Q3(b) (2 marks): The solution in which the seedlings were grown contained various dissolved ions. The table below lists two of the functions of these ions in the seedlings. Comp
  87. November 2020, AS Paper 1, Q15 (1 mark): Which of the rows, A to D, contains the correct elements that are found in proteins? carbon hydrogen oxygen phosphorus nitrogen sulphur A 3 3 3 B 3 3 3 3 3 C 3
  88. November 2020, AS Paper 1, Q16 (1 mark): Oleic acid is a monounsaturated fatty acid found in vegetable oil. Which of the following, A to D, is the correct structure for oleic acid? A HO O B HO O C HO O
  89. November 2020, AS Paper 1, Q18 (1 mark): Human pancreatic lipase breaks the bonds between fatty acids and glycerol. What name is given to this reaction? A condensation B esterification C hydration D hy
  90. November 2020, AS Paper 1, Q19 (1 mark): A conjugated protein is held together by many different types of bond. Which bond is not formed when a conjugated protein folds into its quaternary structure? A
  91. November 2020, AS Paper 1, Q22(a)(i) (3 marks): Describe and explain why collagen is a fibrous protein. [3]
  92. November 2020, AS Paper 1, Q22(a)(ii) (1 mark): Suggest why collagen is such a strong molecule. [1]
  93. November 2020, AS Paper 1, Q22(b) (3 marks): Outline the method of chromatography that will separate the main amino acids in collagen. [3]
  94. November 2020, AS Paper 1, Q22(c)(i) (2 marks): Calculate Rf values for the two highest concentration amino acids. Rf value 1 = Rf value 2 = [2]
  95. November 2020, AS Paper 1, Q22(c)(ii) (2 marks): The table shows the Rf values of a range of amino acids. amino acid Rf value glutamine 0.13 glycine 0.27 isoleucine 0.72 leucine 0.73 methionine 0.55 phenylalan
  96. November 2020, AS Paper 2, Q2(c)(i) (2 marks): A protein is made up of amino acids which are joined by chemical bonds. Below is an incomplete diagram of one of these bonds. Complete the diagram of the molecu
  97. November 2020, AS Paper 2, Q2(c)(ii) (2 marks): The process of esterification leads to the formation of ester bonds during the production of triglycerides. Describe what is meant by the term esterification. [
  98. June 2019, Paper 1, Q13 (1 mark): Collagen is found in tendons. Tendons attach muscles to bones. Which of the following lists of properties, A to D, makes collagen suitable for this role? A stro
  99. June 2019, Paper 1, Q17(c)(i) (1 mark): Name a type of food molecule that the student will not be able to detect using these chemical tests. [1]
  100. June 2019, Paper 1, Q17(c)(ii) (2 marks): The table below is a summary of some of the student’s findings. Complete the table by writing in the missing observations and conclusions. Tube Observation Conc
  101. June 2019, Paper 1, Q17(c)(iii) (1 mark): The student then used a colorimeter to measure the absorbance of the contents of Tube 2. Explain how the use of a colorimeter could improve the student’s conclu
  102. June 2019, Paper 1, Q20(a)(i) (3 marks): Rubredoxin is known as a conjugated protein. Use Fig. 20.1 to explain what is meant by the term conjugated protein. [3]
  103. June 2019, Paper 1, Q20(a)(ii) (2 marks): Using the information provided about rubredoxin, state two similarities between the structures of rubredoxin and haemoglobin. similarity 1 similarity 2 [2]
  104. June 2019, Paper 1, Q20(a)(iii) (2 marks): Rubredoxin and haemoglobin have different secondary and tertiary structures. Using the information provided about rubredoxin, state two other differences betwee
  105. June 2019, Paper 1, Q20(b)(i) (3 marks): Ferritin molecules can hold 4500 Fe3+ ions in the inner sphere. It is thought that the Fe3+ ions are unable to occupy the total available volume of the inner sp
  106. June 2019, Paper 1, Q20(b)(ii) (1 mark): Explain how hydrophilic and hydrophobic interactions contribute to the spherical shape of ferritin. [1]
  107. June 2019, Paper 2, Q16(d) (3 marks): Water has many properties that are essential for living organisms. Explain how properties relating to the density of water contribute to the survival of organis
  108. June 2019, Paper 2, Q21(a)(i) (2 marks): Calculate the number of phospholipid molecules in the outer surface of the lipoprotein shown in Fig. 21. Assume that the pattern of proteins and phospholipids s
  109. June 2019, Paper 2, Q21(a)(ii) (1 mark): Lipoproteins with fewer phospholipids and more protein in the outer layer are known as high density lipoproteins. Lipoproteins with a larger number of phospholi
  110. June 2019, Paper 2, Q21(b) (6 marks): Complete the passage by choosing the most appropriate word from the list. bile carbon hydrogen insoluble nitrogen oxygen permeability production solid soluble s
  111. June 2019, Paper 2, Q21(c) (2 marks): Triglycerides are a type of lipid molecule that can be broken down during hydrolysis reactions. Using the structure of triglyceride molecules as an example, exp
  112. June 2019, AS Paper 1, Q5 (1 mark): The structure of a biological molecule is shown below. CH2OH O OH H H H H OH OH Which of the following options, A to D, correctly describes the molecule? A hexo
  113. June 2019, AS Paper 1, Q6 (1 mark): Which of the following molecules, A to D, could be a product of breaking a peptide bond during a hydrolysis reaction? A B H H O H O H C C N C C N HO H H H CH CH
  114. June 2019, AS Paper 1, Q22(a) (3 marks): Table 22 is a list of practical apparatus used in biological investigations. Each piece of apparatus has been assigned a letter. Letter Apparatus A calorimeter
  115. June 2019, AS Paper 1, Q22(b)(i) (1 mark): Describe how a colorimeter is calibrated. [1]
  116. June 2019, AS Paper 1, Q22(b)(ii) (1 mark): Why is it important to calibrate a colorimeter? [1]
  117. June 2019, AS Paper 1, Q25(a)(i) (1 mark): Name the covalent chemical bond labelled X which links two cysteine amino acids. [1]
  118. June 2019, AS Paper 1, Q25(a)(ii) (1 mark): Name the structure labelled Y which forms part of the secondary structure of lysozyme. [1]
  119. June 2019, AS Paper 1, Q25(a)(iii) (1 mark): Lysozyme consists of a single polypeptide chain of 129 amino acids. State which level of protein structure is not shown by lysozyme. [1]
  120. June 2019, AS Paper 1, Q25(b)(ii) (2 marks): Lysozyme is also known as a glycoside hydrolase. Suggest the type of chemical bond that lysozyme breaks and name the molecule other than the substrate that is n
  121. June 2019, AS Paper 2, Q1(a)(ii) (4 marks): Separate samples of the sap were tested for the presence of glucose, starch and sucrose. Using Table 1, complete the following passage, using the most appropria
  122. June 2019, AS Paper 2, Q1(b)(i) (1 mark): Explain why starch is not transported in the sap. [1]
  123. June 2018, Paper 1, Q2 (1 mark): The following are a series of organic molecules and the chemical processes that occur to convert them into different molecules. Which of the rows, A to D, is co
  124. June 2018, Paper 1, Q3 (1 mark): The following table describes the approximate percentage mass of different chemical elements in organic polymers. N C O H P Polymer (%) (%) (%) (%) (%) A nuclei
  125. June 2018, Paper 1, Q18(b) (3 marks): Plant cell walls are made of cellulose. Cellulose is a polymer of β-glucose. Give three properties of cellulose that make it suitable as the basis of plant cell
  126. June 2018, Paper 1, Q19(b) (4 marks): Chitin is a polysaccharide found in insects. It is used to form the hard outer casing of their bodies. Fig. 19.2 shows the chemical structure of chitin. CH2OH C
  127. June 2018, Paper 2, Q4 (1 mark): Which of the following processes involves the formation of ester bonds? 1 synthesis of polynucleotides 2 synthesis of triglycerides 3 synthesis of polypeptides
  128. June 2018, Paper 2, Q5 (1 mark): Which of the following could not be an amino acid? A B NH NH2 O HO HO OH O O NH2 C D OH NH2 O HO H2N OH OH Your answer [1]
  129. June 2018, Paper 2, Q6 (1 mark): Lipids are a diverse group of chemicals that are neither polar nor charged and hence are insoluble in water. The ___(1)___ nature of the heads of phospholipids
  130. June 2018, Paper 2, Q22(a) (1 mark): Compound W shows some structural similarities with fatty acids. State one structural difference between compound W and a saturated fatty acid. [1]
  131. June 2018, Paper 3, Q2(b) (3 marks): Glucose and other carbohydrates are present in respiring cells. The concentrations of carbohydrate molecules vary between tissues. A student conducted tests on
  132. June 2018, AS Paper 1, Q4 (1 mark): The image below shows isomaltulose, a disaccharide formed from α-glucose and fructose. CH2OH O H H H OH H O HO H O OH H OH H H OH H CH2OH OH H Name the bond tha
  133. June 2018, AS Paper 1, Q11 (1 mark): The hydroxyl (-OH) group of carbohydrates is polar and makes the molecule soluble in water. The greater the number of free hydroxyl groups as a proportion of th
  134. June 2018, AS Paper 1, Q19 (1 mark): The table below shows four biological molecules and their component elements. Which of the rows, A to D, correctly identifies the elements in each molecule? suc
  135. June 2018, AS Paper 1, Q21(b) (2 marks): Outline the properties of water which make it an ideal habitat for an amphibian. [2]
  136. June 2018, AS Paper 1, Q22(a) (1 mark): On Fig. 22 circle an ester bond. [Answer on Fig. 22] [1]
  137. June 2018, AS Paper 1, Q22(b) (1 mark): Sunflower oil is used to make biodiesel, which contains methyl esters. The fatty acids in the triglyceride molecule are reacted with methanol in a process calle
  138. June 2018, AS Paper 1, Q22(c)(i) (3 marks): Name three other functions of triglycerides in living organisms. 1 2 3 [3]
  139. June 2018, AS Paper 1, Q22(c)(ii) (2 marks): Table 22 shows the melting points of some of the methyl esters made from the transesterification of sunflower oil fatty acids. Methyl ester Formula Melting poin
  140. June 2018, AS Paper 2, Q1(a)(i) (1 mark): State the names of the groups labelled U and V. U V [1]
  141. June 2018, AS Paper 2, Q1(a)(ii) (1 mark): Fig. 1.2 shows a representation of a short polypeptide chain made from three amino acids. Valine Bond W Alanine Glycine Fig. 1.2 Name bond W and state what type
  142. June 2018, AS Paper 2, Q1(b)(iii) (6 marks): (iii)* Titin is a fibrous protein. Pepsin is a globular protein. Compare the properties and functions of fibrous proteins and globular proteins in the human bod
  143. June 2018, AS Paper 2, Q1(c)(i) (4 marks): Describe four ways you would refine the method used by the students. For each change you suggest, give a reason why this would improve the results of the experi
  144. June 2018, AS Paper 2, Q1(c)(ii) (2 marks): Table 1 shows the Rf values of some amino acids. Name of amino acid Rf value Alanine 0.31 Cysteine 0.40 Glutamine 0.13 Phenylalanine 0.59 Table 1 Using the info
  145. June 2018, AS Paper 2, Q4(a)(i) (2 marks): Ions have a number of important roles in living organisms. Complete the table below by identifying the ion that plays each of the roles. Choose from the followi
  146. June 2017, Paper 1, Q18(c)(i) (2 marks): Soluble mineral ions are present in soil. –) ions. Explain why water molecules can form hydrogen bonds with nitrate (NO3 [2]
  147. June 2017, Paper 2, Q2 (1 mark): Which of the statements, A to D, about amylopectin is correct? A it contains 1-4 and 1-6 glycosidic bonds between α-glucose monomers B it is an unbranched chain
  148. June 2017, Paper 2, Q20(a)(i) (2 marks): State two other structural similarities between lactose and maltose. 1 2 [2]
  149. June 2017, Paper 2, Q20(a)(ii) (3 marks): Complete the table below to identify differences between the structures of lactose and maltose. The first one has been completed for you. Lactose Maltose one gl
  150. June 2017, Paper 2, Q20(b)(i) (3 marks): Explain how the structure of galactose allows it to be used as a respiratory substrate. [3]
  151. June 2017, Paper 2, Q20(c) (4 marks): Lactose is a reducing sugar. Benedict’s reagent can be used to detect the presence of lactose in a solution. A colorimeter can be used to measure the concentrat
  152. June 2017, Paper 3, Q1(a)(i) (1 mark): On Fig. 1.1, draw a circle around the R group of leucine. H H3C C CH3 CH2 H2N C COOH H Fig. 1.1 [1]
  153. June 2017, Paper 3, Q1(a)(ii) (1 mark): Students used thin layer chromatography to separate leucine from other amino acids. The chromatogram they produced is shown in Fig. 1.2. Y X leucine origin solv
  154. June 2017, Paper 3, Q1(a)(iii) (3 marks): Amino acid Z was in the mixture analysed by the students. It is not shown on the chromatogram in Fig. 1.2. Amino acid Z has an Rf value that is 0.20 lower than
  155. June 2017, Paper 3, Q1(b)(i) (1 mark): State a material that can be used as the stationary phase in thin layer chromatography. [1]
  156. June 2017, Paper 3, Q1(c) (3 marks): When sequencing DNA, fragments of DNA are separated by electrophoresis. Describe three differences between the process of thin layer chromatography and the form
  157. June 2017, Paper 3, Q2(a)(i) (2 marks): The table below contains statements about the structures of gluten polypeptides. In the boxes next to each statement, write the level of protein structure (prim
  158. June 2017, AS Paper 1, Q7 (1 mark): Water is known as the universal solvent as it has the ability to dissolve many ionic and covalent compounds due to its polar nature. Which of the 3-carbon compo
  159. June 2017, AS Paper 1, Q8 (1 mark): Which of the options, A to D, is a correct statement about polysaccharides of glucose? A Cellulose microfibrils are formed by hydrogen bonding between adjacent
  160. June 2017, AS Paper 1, Q10 (1 mark): A group of students was given a 1% solution of an unknown digestive enzyme. They were also given three tubes containing an identical mixture of foods. The stude
  161. June 2017, AS Paper 1, Q22(a) (3 marks): Explain why mammals store glycogen instead of glucose. [3]
  162. June 2017, AS Paper 2, Q6(a)(i) (3 marks): Plot a graph of the mean % absorbance at each glucose concentration. [3]
  163. June 2017, AS Paper 2, Q6(a)(ii) (2 marks): The students were provided with three different fruit juices labelled A, B and C. The Benedict’s test was carried out on each fruit juice and samples were prepa
  164. June 2017, AS Paper 2, Q6(b)(i) (4 marks): Describe how you would carry out a controlled experiment to test this hypothesis without using a colorimeter. [4]
  165. June 2017, AS Paper 2, Q6(b)(ii) (1 mark): Suggest one reason why the results for this experiment might not support the students’ hypothesis. [1]
  166. June 2017, AS Paper 2, Q6(c)(i) (2 marks): State two ways in which the molecular structure of cholesterol is similar to the molecular structure of glucose. [2]
  167. June 2017, AS Paper 2, Q6(c)(ii) (1 mark): Glucose is an important biological molecule required by cells for cellular respiration. State the physical property of glucose that allows it to be easily trans
  168. June 2016, AS Paper 1, Q2 (1 mark): Carbohydrates, such as starch, are made from monosaccharides joined together. Which of the bonds, A to D, joins monosaccharides together? A ester B glycosidic C
  169. June 2016, AS Paper 1, Q11 (1 mark): A student investigates some solutions, X, Y and Z, using paper chromatography. The results are shown below. solvent front X Y Z Which of the following options,
  170. June 2016, AS Paper 2, Q3(a)(i) (1 mark): How does the composition of N-acetylglucosamine differ from the composition of a monosaccharide sugar? [1]
  171. June 2016, AS Paper 2, Q3(a)(ii) (2 marks): Which monosaccharide sugar does N-acetylglucosamine most closely resemble? [2]
  172. June 2016, AS Paper 2, Q3(a)(iii) (4 marks): Using your knowledge of the formation of structural polysaccharides, describe the formation of the chitin molecule from its monomer and predict its structure. [

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