plumiMaking and inserting recombinant DNA: Edexcel International A Level Biology questions
Edexcel International A Level Biology past-paper questions on 8.6.2 Making and inserting recombinant DNA, 2019–2025, with mark schemes and examiner’s reports where available.
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Q7(d)(i)
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All 18 questions on Making and inserting recombinant DNA, as a list
- June 2025, Unit 5, Q7(d)(i) (4 marks): Describe how mouse cells can be genetically modified to synthesise human GH. (4)
- June 2025, Unit 5, Q8(c) (2 marks): Describe the roles of nucleic acids and enzymes used in CRISPR gene editing to remove some of the Y chromosome genes (paragraph 5). (2)
- January 2025, Unit 5, Q5(c)(i) (3 marks): Describe how enzymes can be used to genetically modify the bacteria to produce human insulin. (3)
- October 2024, Unit 4, Q2(b)(ii) (3 marks): The results of the gel electrophoresis were used to identify the plants that contained the resistance genes. Deduce the types of plants that would have supplied
- October 2024, Unit 5, Q7(a) (1 mark): Which is a description of a GM organism? (1) A an amplified sequence of nucleic acid B an organism containing genetic material from another species C a virus co
- June 2024, Unit 5, Q8(c) (4 marks): Explain how populations of fluorescent red zebrafish could be produced for breeding (paragraphs 9 and 15). (4)
- January 2024, Unit 5, Q5(c)(ii) (4 marks): The symptoms of Prader–Willi syndrome can be treated using human growth hormone (HGH). This hormone is a protein produced by the pituitary gland. Describe how E
- October 2023, Unit 5, Q1(a)(i) (1 mark): Which enzyme is used in the production of recombinant DNA? (1) A acetylcholinesterase B amylase C restriction endonuclease D RNA polymerase
- October 2023, Unit 5, Q5(b) (4 marks): The diagram shows how serotonin is produced from tryptophan. TRYPTOPHAN 5HTP SEROTONIN Enzyme A Enzyme B Enzymes A and B are found in the Madagascar periwinkle.
- October 2022, Unit 5, Q7(a)(i) (4 marks): Sheep have been genetically modified to produce rHE in their milk. Explain how a sheep could be genetically modified to produce rHE in its milk. (4)
- June 2022, Unit 5, Q4(b)(ii) (3 marks): Describe how tomato plants could be genetically modified to make the enzyme that converts tyrosine to L‑dopa. (3)
- January 2022, Unit 5, Q7(c) (4 marks): One potential treatment for AAT deficiency uses adenoviruses to genetically modify cells in an affected person. Adenoviruses contain double‑stranded DNA. Explai
- October 2021, Unit 5, Q2(a) (4 marks): Describe how genetic engineering could be used to produce rice that contains β‑carotene. (4)
- January 2021, Unit 4, Q7(a)(i) (1 mark): Which enzyme is used to cut the DNA into fragments? (1) A DNA polymerase B integrase C restriction enzyme D reverse transcriptase
- January 2021, Unit 5, Q5(b) (4 marks): Scientists are investigating the use of gene therapy to treat blindness caused by mutations in the RPE65 gene. In one investigation, different gene therapy dose
- January 2021, Unit 5, Q8(e)(i) (4 marks): Describe how insect cells could be genetically modified to produce the antigens for an Ebola vaccine. (4)
- October 2020, Unit 4, Q4(b)(i) (2 marks): Explain how attaching the gene for TNF to the viral gene results in TNF being displayed on the outside of the capsid. (2)
- January 2020, Unit 4, Q8(b)(ii) (2 marks): Explain why the CAR gene is inserted into the T cells in Step 3. (2)
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