plumiHormonal coordination in humans: AQA GCSE Biology questions
Every AQA GCSE Biology exam question on 4.5.3 Hormonal coordination in humans, 2018–2025, with its mark scheme and examiner’s report.
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Q04.1
The whole paper ↗![June 2025 Paper 2 Higher, question 04.1: Name one other hormone made by the pituitary gland. [1 mark]](https://pub-e8a9dbab8e2a4d089f52b2a45e0d0b50.r2.dev/bank/84612h-jun25-04-1-qp.webp)
Q04.2
The whole paper ↗
Q09.1
The whole paper ↗
Q09.3
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Q03.1
The whole paper ↗![June 2025 Paper 2 Foundation, question 03.1: Where in the body are sperm cells produced? [1 mark]](https://pub-e8a9dbab8e2a4d089f52b2a45e0d0b50.r2.dev/bank/84612f-jun25-03-1-qp.webp)
Q04.1
The whole paper ↗![June 2025 Paper 2 Foundation, question 04.1: Complete Figure 7. [2 marks] You should: • plot the data for sweat and for breathing from Table 2 • label each bar.](https://pub-e8a9dbab8e2a4d089f52b2a45e0d0b50.r2.dev/bank/84612f-jun25-04-1-qp.webp)
Q04.3
The whole paper ↗![June 2025 Paper 2 Foundation, question 04.3: The kidneys control the amount of water in the body. Draw one line from each process in the kidneys to the name of that process. [3 marks]](https://pub-e8a9dbab8e2a4d089f52b2a45e0d0b50.r2.dev/bank/84612f-jun25-04-3-qp.webp)
Q04.4
The whole paper ↗
Q05.2
The whole paper ↗
Q05.3
The whole paper ↗![June 2024 Paper 2 Higher, question 05.3: Name one hormone produced by gland A. [1 mark]](https://pub-e8a9dbab8e2a4d089f52b2a45e0d0b50.r2.dev/bank/84612h-jun24-05-3-qp.webp)
Q05.4
The whole paper ↗![June 2024 Paper 2 Higher, question 05.4: Name one hormone produced by gland B. [1 mark]](https://pub-e8a9dbab8e2a4d089f52b2a45e0d0b50.r2.dev/bank/84612h-jun24-05-4-qp.webp)
Q05.5
The whole paper ↗![June 2024 Paper 2 Higher, question 05.5: The adrenal gland produces the hormone adrenaline. Describe two effects of adrenaline on the human body. [2 marks] 1 2](https://pub-e8a9dbab8e2a4d089f52b2a45e0d0b50.r2.dev/bank/84612h-jun24-05-5-qp.webp)
Q05.6
The whole paper ↗![June 2024 Paper 2 Higher, question 05.6: Hormones can be used for controlling human reproduction. Explain the use of hormones in: • contraception • the treatment of infertility. [6 marks]](https://pub-e8a9dbab8e2a4d089f52b2a45e0d0b50.r2.dev/bank/84612h-jun24-05-6-qp.webp)
Q08.2
The whole paper ↗![June 2024 Paper 2 Higher, question 08.2: Describe what happens to glucose, protein and urea in the kidneys. [4 marks]](https://pub-e8a9dbab8e2a4d089f52b2a45e0d0b50.r2.dev/bank/84612h-jun24-08-2-qp.webp)
Q08.3
The whole paper ↗![June 2024 Paper 2 Higher, question 08.3: Explain how ADH affects the production and concentration of urine by the kidneys. [4 marks]](https://pub-e8a9dbab8e2a4d089f52b2a45e0d0b50.r2.dev/bank/84612h-jun24-08-3-qp.webp)
Q01.5
The whole paper ↗![June 2024 Paper 2 Foundation, question 01.5: Which structure in Figure 1 is the pituitary gland? [1 mark] Tick () one box. A B C D](https://pub-e8a9dbab8e2a4d089f52b2a45e0d0b50.r2.dev/bank/84612f-jun24-01-5-qp.webp)
Q05.1
The whole paper ↗![June 2024 Paper 2 Foundation, question 05.1: Which organ produces insulin? [1 mark] Tick () one box. Adrenal gland Pancreas Thyroid People with Type 2 diabetes: • produce insulin • have body cells that do](https://pub-e8a9dbab8e2a4d089f52b2a45e0d0b50.r2.dev/bank/84612f-jun24-05-1-qp.webp)
Q05.2
The whole paper ↗![June 2024 Paper 2 Foundation, question 05.2: Why do people with Type 2 diabetes often have a high concentration of glucose in their blood? [1 mark] Tick () one box. The body cells change glucose into glyc](https://pub-e8a9dbab8e2a4d089f52b2a45e0d0b50.r2.dev/bank/84612f-jun24-05-2-qp.webp)
Q05.3
The whole paper ↗![June 2024 Paper 2 Foundation, question 05.3: Give two control variables used in the investigation. [2 marks] 1 2 Figure 6 shows the results. Figure 6](https://pub-e8a9dbab8e2a4d089f52b2a45e0d0b50.r2.dev/bank/84612f-jun24-05-3-qp.webp)
All 95 questions on Hormonal coordination in humans, as a list
- June 2025, Paper 2 Higher, Q04.1 (1 mark): Name one other hormone made by the pituitary gland. [1 mark]
- June 2025, Paper 2 Higher, Q04.2 (1 mark): hGH is a protein. A child with a deficiency of hGH can be given injections of hGH. What would happen to the hGH if it was given as a tablet that was swallowed?
- June 2025, Paper 2 Higher, Q09.1 (2 marks): Scientists recorded the percentage of people of different ages who had Type 2 diabetes. The people were in different weight categories: • healthy weight • overw
- June 2025, Paper 2 Higher, Q09.2 (1 mark): For the patients treated with drug B the mean percentage of Hb-G at the start was 8.3%. What was the mean percentage of Hb-G after 12 weeks for the patients tre
- June 2025, Paper 2 Higher, Q09.3 (6 marks): In a person without diabetes, the Hb-G value is between 4.5% and 6%. When treating patients with Type 2 diabetes, doctors think that an Hb-G value <7% is accept
- June 2025, Paper 2 Foundation, Q03.1 (1 mark): Where in the body are sperm cells produced? [1 mark]
- June 2025, Paper 2 Foundation, Q04.1 (2 marks): Complete Figure 7. [2 marks] You should: • plot the data for sweat and for breathing from Table 2 • label each bar.
- June 2025, Paper 2 Foundation, Q04.3 (3 marks): The kidneys control the amount of water in the body. Draw one line from each process in the kidneys to the name of that process. [3 marks]
- June 2025, Paper 2 Foundation, Q04.4 (4 marks): A person with kidney failure can be treated by dialysis or by a kidney transplant. For dialysis: • a person needs 3 dialysis sessions each week • each session c
- June 2024, Paper 2 Higher, Q05.2 (2 marks): Student B’s reaction is coordinated by the nervous system. Give two ways that coordination by the endocrine system is different from coordination by the nervous
- June 2024, Paper 2 Higher, Q05.3 (1 mark): Name one hormone produced by gland A. [1 mark]
- June 2024, Paper 2 Higher, Q05.4 (1 mark): Name one hormone produced by gland B. [1 mark]
- June 2024, Paper 2 Higher, Q05.5 (2 marks): The adrenal gland produces the hormone adrenaline. Describe two effects of adrenaline on the human body. [2 marks] 1 2
- June 2024, Paper 2 Higher, Q05.6 (6 marks): Hormones can be used for controlling human reproduction. Explain the use of hormones in: • contraception • the treatment of infertility. [6 marks]
- June 2024, Paper 2 Higher, Q08.2 (4 marks): Describe what happens to glucose, protein and urea in the kidneys. [4 marks]
- June 2024, Paper 2 Higher, Q08.3 (4 marks): Explain how ADH affects the production and concentration of urine by the kidneys. [4 marks]
- June 2024, Paper 2 Foundation, Q01.5 (1 mark): Which structure in Figure 1 is the pituitary gland? [1 mark] Tick () one box. A B C D
- June 2024, Paper 2 Foundation, Q05.1 (1 mark): Which organ produces insulin? [1 mark] Tick () one box. Adrenal gland Pancreas Thyroid People with Type 2 diabetes: • produce insulin • have body cells that do
- June 2024, Paper 2 Foundation, Q05.2 (1 mark): Why do people with Type 2 diabetes often have a high concentration of glucose in their blood? [1 mark] Tick () one box. The body cells change glucose into glyc
- June 2024, Paper 2 Foundation, Q05.3 (2 marks): Give two control variables used in the investigation. [2 marks] 1 2 Figure 6 shows the results. Figure 6
- June 2024, Paper 2 Foundation, Q05.4 (2 marks): Group B reached a maximum value earlier than group A. Determine how many minutes earlier. [2 marks] Number of minutes earlier =
- June 2024, Paper 2 Foundation, Q05.5 (2 marks): Give two conclusions about the effect of drug X on the concentration of glucose in the blood. Do not refer to reaching the maximum value earlier. [2 marks] 1 2
- June 2024, Paper 2 Foundation, Q05.6 (1 mark): How could scientists find the best dose of drug X for controlling blood glucose concentration? [1 mark] Tick () one box. Repeat the investigation twice more. U
- June 2023, Paper 2 Higher, Q05.1 (3 marks): Figure 8 shows how the concentration of substance Q in the blood is controlled by negative feedback. Figure 8 Explain how the concentration of substance Q in th
- June 2023, Paper 2 Higher, Q05.2 (2 marks): Thyroxine is a hormone produced by the thyroid gland. A decrease in body temperature causes an increase in thyroxine production. Explain how the production of t
- June 2023, Paper 2 Higher, Q05.3 (4 marks): ADH is a hormone made by the pituitary gland. ADH controls how much water is reabsorbed from the kidney tubules. Table 2 shows effects of ADH. Table 2 Concentra
- June 2023, Paper 2 Higher, Q07.1 (1 mark): Give evidence from Figure 12 that the follicles in the ovaries release oestrogen. [1 mark]
- June 2023, Paper 2 Higher, Q07.2 (5 marks): Injection of FSH caused the development of a number of follicles. The mean diameter of the follicles on day 11 was 22 millimetres. Calculate the number of folli
- June 2023, Paper 2 Higher, Q07.3 (2 marks): Before treatment with FSH, the woman had underdeveloped breasts. Explain why the lack of FSH in the woman’s blood caused underdeveloped breasts. [2 marks]
- June 2023, Paper 2 Foundation, Q01.1 (1 mark): Which organ system has glands that produce hormones? [1 mark] Tick () one box. The circulatory system The endocrine system The nervous system
- June 2023, Paper 2 Foundation, Q01.2 (1 mark): How are hormones transported around the body? [1 mark] Tick () one box. By the blood By the muscles By the nerves
- June 2023, Paper 2 Foundation, Q01.3 (3 marks): Draw one line from each gland to the name of that gland. [3 marks] Gland Name A B C Adrenal Pituitary Testes Thyroid
- June 2023, Paper 2 Foundation, Q01.4 (1 mark): Which gland in Figure 1 produces insulin? [1 mark] Tick () one box. A B C D
- June 2023, Paper 2 Foundation, Q01.5 (1 mark): Which organ does insulin mainly affect? [1 mark] Tick () one box. The brain The liver The ovary
- June 2023, Paper 2 Foundation, Q01.6 (1 mark): Give one effect of insulin. [1 mark]
- June 2023, Paper 2 Foundation, Q01.7 (1 mark): Which hormone causes an egg to mature in the ovary? [1 mark] Tick () one box. Adrenaline Follicle stimulating hormone (FSH) Testosterone
- June 2023, Paper 2 Foundation, Q01.8 (2 marks): Which two are hormones that help to maintain the lining of the uterus during pregnancy? [2 marks] Tick () two boxes. Amylase Oestrogen Progesterone Protease Th
- June 2023, Paper 2 Foundation, Q01.9 (2 marks): Contraception prevents pregnancy. Give two methods of contraception that use hormones. [2 marks] 1 2
- June 2023, Paper 2 Foundation, Q06.1 (2 marks): Glucose molecules are found in the blood plasma and in the filtrate. Protein molecules are only found in the blood plasma. Draw one line from each substance to
- June 2023, Paper 2 Foundation, Q06.2 (1 mark): The kidneys control the volume of water in the body. Table 4 shows information about a person on one day. Table 4 Volume in dm3 Water filtered from blood 160.0
- June 2023, Paper 2 Foundation, Q06.3 (6 marks): A person with kidney disease may be treated by dialysis or by having a kidney transplant. Figure 11 gives information about dialysis and kidney transplants. Fig
- June 2023, Paper 2 Foundation, Q06.4 (3 marks): A kidney transplant costs £17 000 in the first year and then £5 000 in each of the following years for drugs. Calculate the total cost of treatment by kidney tr
- June 2022, Paper 2 Higher, Q03.1 (1 mark): Give one time when the concentration of insulin in the person’s blood would be high. Use Figure 2. [1 mark] Time = hours
- June 2022, Paper 2 Higher, Q03.2 (3 marks): Explain the effect a high concentration of insulin has on blood glucose concentration. [3 marks] Effect Explanation
- June 2022, Paper 2 Higher, Q03.3 (1 mark): Person A: • is 1.75 m in height • has a body mass of 52 kg. What is person A’s weight category? [1 mark] Tick () one box. Underweight Healthy weight Overweight
- June 2022, Paper 2 Higher, Q03.4 (1 mark): Person B is 1.9 m in height. Give the range of body masses that would put person B in the healthy weight category. [1 mark] Range from kg to kg
- June 2022, Paper 2 Higher, Q03.5 (2 marks): Person C is obese. A doctor thinks that person C has Type 2 diabetes. The doctor tests a sample of blood from person C. Table 2 shows: • the results of the bloo
- June 2022, Paper 2 Higher, Q03.6 (2 marks): Give two ways that a person can reduce the chance of developing Type 2 diabetes. [2 marks] 1 2
- June 2022, Paper 2 Higher, Q05.3 (1 mark): One of the final products shown in Figure 5 is urea. Where in the human body are the reactions shown in Figure 5 most likely to occur? [1 mark] Tick () one box
- June 2022, Paper 2 Higher, Q05.5 (2 marks): Explain why the urine of a person with MSUD will have a high concentration of toxic substance P. [2 marks]
- June 2022, Paper 2 Higher, Q08.2 (2 marks): Explain why the decrease in body temperature is an advantage to the echidna during hibernation. [2 marks]
- June 2022, Paper 2 Higher, Q08.6 (1 mark): Suggest why the athlete was advised to take salt tablets each day. [1 mark]
- June 2022, Paper 2 Foundation, Q05.1 (2 marks): Which two hormones are female reproductive hormones? [2 marks] Tick () two boxes. Adrenaline Oestrogen Progesterone Testosterone Thyroxine
- June 2022, Paper 2 Foundation, Q05.2 (1 mark): Follicle stimulating hormone (FSH) is another female reproductive hormone. What is the function of FSH in the menstrual cycle? [1 mark] Tick () one box. FSH ca
- June 2022, Paper 2 Foundation, Q05.3 (1 mark): Sperm cells can survive inside a woman’s reproductive organs for five days. An egg cell can survive for one day after ovulation. In one woman ovulation occurred
- June 2022, Paper 2 Foundation, Q05.4 (6 marks): If a man and a woman have sexual intercourse and do not want to produce a baby, they may use contraception. Explain how different methods of contraception preve
- June 2022, Paper 2 Foundation, Q10.1 (1 mark): Give one time when the concentration of insulin in the person’s blood would be high. Use Figure 13. [1 mark] Time = hours
- June 2022, Paper 2 Foundation, Q10.2 (3 marks): Explain the effect a high concentration of insulin has on blood glucose concentration. [3 marks] Effect Explanation
- June 2022, Paper 2 Foundation, Q10.3 (1 mark): Person A: • is 1.75 m in height • has a body mass of 52 kg. What is person A’s weight category? [1 mark] Tick () one box. Underweight Healthy weight Overweight
- June 2022, Paper 2 Foundation, Q10.4 (1 mark): Person B is 1.9 m in height. Give the range of body masses that would put person B in the healthy weight category. [1 mark] Range from kg to kg
- June 2022, Paper 2 Foundation, Q10.5 (2 marks): Person C is obese. A doctor thinks that person C has Type 2 diabetes. The doctor tests a sample of blood from person C. Table 5 shows: • the results of the bloo
- June 2022, Paper 2 Foundation, Q10.6 (2 marks): Give two ways that a person can reduce the chance of developing Type 2 diabetes. [2 marks] 1 2
- November 2021, Paper 2 Higher, Q06.3 (3 marks): The endocrine system coordinates many internal functions of the body. Give three ways coordination by the endocrine system is different from coordination by the
- November 2021, Paper 2 Higher, Q06.4 (5 marks): Describe how hormones control the menstrual cycle. [5 marks]
- November 2021, Paper 2 Foundation, Q02.1 (1 mark): Which gland is the pituitary gland? [1 mark] Tick () one box. A B C D
- November 2021, Paper 2 Foundation, Q02.2 (1 mark): Which gland is the pancreas? [1 mark] Tick () one box. A B C D
- November 2021, Paper 2 Foundation, Q02.3 (1 mark): Which of the following is a target organ for insulin? [1 mark] Tick () one box. Bladder Heart Liver
- November 2021, Paper 2 Foundation, Q02.4 (1 mark): The glucose is stored as an insoluble substance. What is the insoluble storage substance that is formed from glucose? [1 mark] Tick () one box. Glycogen Protei
- November 2021, Paper 2 Foundation, Q02.5 (2 marks): At the start of the investigation, the blood glucose concentration was 5 mmol/dm3. Calculate the highest blood glucose concentration during the investigation. U
- November 2021, Paper 2 Foundation, Q02.6 (1 mark): What is the time taken for the blood glucose concentration to decrease from its highest value back to the starting value? Use data from Figure 3 in your answer.
- November 2021, Paper 2 Foundation, Q02.7 (1 mark): Why can you not be certain that your answer to Question 02.6 is accurate? [1 mark]
- November 2021, Paper 2 Foundation, Q02.8 (2 marks): Figure 3 shows the results for a person who does not have Type 2 diabetes. Sketch a line on Figure 3 to show the results you would expect for a person who has T
- November 2020, Paper 2 Foundation, Q04.1 (2 marks): The total water loss was 2600 cm3. Calculate the percentage of the total water loss that was lost as urine. [2 marks] Percentage lost as urine = %
- November 2020, Paper 2 Foundation, Q04.3 (1 mark): What must marathon runners do to prevent themselves becoming dehydrated? [1 mark]
- November 2020, Paper 2 Foundation, Q04.4 (3 marks): Complete the sentences. [3 marks] Choose answers from the box. digestion excretion fertilisation filtration reabsorption Blood entering the kidneys goes through
- November 2020, Paper 2 Foundation, Q04.5 (4 marks): People with kidney failure can have dialysis or a kidney transplant. Dialysis is often needed 3 times each week and can take over 4 hours each time. Dialysis us
- November 2020, Paper 2 Foundation, Q05.1 (3 marks): Label A, B and C on Figure 6. [3 marks] Choose answers from the box. cerebellum cerebral cortex medulla pituitary gland
- Specimen, Paper 2 Higher, Q09.1: Explain how blood glucose levels are controlled in the body of someone who does not have diabetes. [4 mar
- Specimen, Paper 2 Higher, Q09.2: Compare how each type of diabetes is caused. Suggest how each type of diabetes can be treated. [4 mar 3
- Specimen, Paper 2 Higher, Q09.3 (3 marks): Look at Table 5. Table 5 Population of UK in 2015 6.5 × 107 Number of people diagnosed with diabetes 3.45 × 106 Estimated number of people with undiagnosed diab
- Specimen, Paper 2 Higher, Q09.4: A urine test can be used to check for the presence of glucose in the urine. Diabetes can also be diagnosed with a blood test to measure the concentration of blo
- Specimen, Paper 2 Higher, Q09.5: A blood test called the glucose tolerance test checks how well the body processes glucose. Concentrations of glucose in the blood are measured before and after
- Specimen, Paper 2 Higher, Q09.6 (2 marks): Figure 11 shows the results of a glucose tolerance test for two patients, A and B. Figure 11 Which patient has diabetes? Justify your answer. [2 marks Patient J
- Specimen, Paper 2 Higher, Q10.1: Hyperthyroidism is caused by an overactive thyroid gland. Suggest what would happen in the body of a person with hyperthyroidism. [3 mar
- Specimen, Paper 2 Higher, Q10.2: Describe the roles of FSH and LH in the menstrual cycle. [2 mar 35
- Specimen, Paper 2 Higher, Q10.3 (4 marks): The combined pill is a contraceptive that contains progesterone and oestrogen. The ‘mini-pill’: • is a contraceptive that only contains the progesterone hormone
- Specimen, Paper 2 Foundation, Q04.1: Name organ A. [1 ma
- Specimen, Paper 2 Foundation, Q04.2: Organ A stores glucose. People with Type 1 diabetes cannot effectively control the levels of glucose in their blood. Name the hormone people with Type 1 diabete
- Specimen, Paper 2 Foundation, Q04.3 (1 mark): Which organ produces urine? [1 mark Tick one box. Brain Lungs Kidney Thyroid
- Specimen, Paper 2 Foundation, Q04.4 (2 marks): Marathon runners often drink sports drinks during a race. Explain why. [2 marks
- Specimen, Paper 2 Foundation, Q09.1: Use words from the box to label gland A and gland B on Figure 13. [2 mar Adrenal Pancreas Pituitary Testis Thyroid Figure 13
- Specimen, Paper 2 Foundation, Q09.2: Which gland produces oestrogen? [1 ma Tick one box. Ovary Pancreas Testis Thyroid 33
- Specimen, Paper 2 Foundation, Q09.3 (1 mark): Which method of contraception in Table 4 is least effective at preventing pregnancy? [1 mark
- Specimen, Paper 2 Foundation, Q09.4 (1 mark): Which method of contraception in Table 4 will protect against sexually transmitted diseases like HIV? [1 mark 3 Another method of contraception is called the in
- Specimen, Paper 2 Foundation, Q09.5 (4 marks): Evaluate the use of the plastic IUD as a contraceptive compared to the copper IUD. Use the information in Table 5. [4 marks 36
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