Coenzymes and cofactors: OCR A‑Level Biology A questions
OCR A-Level Biology A past-paper questions on 2.1.4.4 Coenzymes and cofactors, 2016–2025, with mark schemes and examiner’s reports where available.
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Calculations
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Q2(d)(i)
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Q27(a)(ii)
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- Your answer

Q3(b)
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Q4(b)(i)
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All 10 questions on Coenzymes and cofactors, as a list
- June 2023, Paper 2, Q15 (1 mark): The image below shows an enzyme and its substrate. Enzyme Substrate Which option represents a coenzyme for this enzyme? A B C D [1] Your answer
- June 2023, Paper 3, Q2(d)(i) (2 marks): Vitamin C acts as a coenzyme for several enzymes in the synthesis of collagen. Outline the role of coenzymes in biological reactions. [2]
- June 2023, AS Paper 1, Q27(a)(ii) (1 mark): Vitamin C binds to TET enzymes and increases their catalytic activity. State the role of vitamin C when it binds to a TET enzyme. [1]
- June 2022, AS Paper 1, Q2 (1 mark): The reaction between carbon dioxide and water forms carbonic acid. This reaction is catalysed by the enzyme carbonic anhydrase. To catalyse this reaction, carbo
- November 2021, Paper 1, Q18(b) (3 marks): Liver is a rich source of the enzyme catalase. The table below describes examples of three terms from the list below. coenzyme competitive inhibition enzyme-pro
- June 2019, Paper 3, Q3(b) (2 marks): One example of a cold-tolerant molecule present in icefish is a modified form of the protease enzyme trypsin. Fig. 3 shows how trypsin is converted from a molec
- June 2019, AS Paper 1, Q8 (1 mark): Which of the following ions, A to D, is required for the hydrolysis of starch by an enzyme? Cl – A K+ B Na+ C Zn2+ D Your answer [1]
- June 2017, Paper 3, Q4(b)(i) (4 marks): What can you conclude from Fig. 4 about the molecules or ions that affect the functioning of the nitrogenase enzyme? [4]
- June 2017, AS Paper 1, Q19 (1 mark): What is the correct definition of the term coenzyme? A An inorganic ion that forms the centre of a globular protein. B A molecule that binds to the enzyme, chan
- June 2016, AS Paper 1, Q3 (1 mark): Some inorganic ions have roles in enzyme-controlled reactions. Which of the rows, A to D, in the table below is correct? Role of ion Prosthetic group for Cofact
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