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Transcription and translation: Edexcel International A Level Biology questions

Edexcel International A Level Biology past-paper questions on 2.5.2 Transcription and translation, 2019–2025, with mark schemes and examiner’s reports where available.

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  1. Q5(b)

    June 2025 · AS Unit 1

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  2. The start of question 5

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  3. Q5(c)(ii)

    June 2025 · AS Unit 1

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  5. Q6(c)(iii)

    January 2025 · AS Unit 1

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  6. Q7(b)(iii)

    January 2025 · AS Unit 2

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  7. Q5(b)(i)

    October 2024 · AS Unit 1

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  8. Q3(a)

    June 2024 · AS Unit 1

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  9. Q3(b)

    June 2024 · AS Unit 1

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  10. Q3(c)

    June 2024 · AS Unit 1

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  11. Q3(a)

    October 2023 · AS Unit 1

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  12. Q3(b)(i)

    October 2023 · AS Unit 1

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  13. Q3(b)(ii)

    October 2023 · AS Unit 1

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  14. Q1(a)(i)

    June 2023 · AS Unit 1

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  15. Q1(a)(ii)

    June 2023 · AS Unit 1

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  16. Q1(a)(iii)

    June 2023 · AS Unit 1

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  17. The start of question 8

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  18. Q8(a)(i)

    January 2023 · Unit 4

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  19. Q6(b)(iii)

    October 2021 · AS Unit 1

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  20. Q2(b)(ii)

    October 2021 · Unit 4

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All 27 questions on Transcription and translation, as a list
  1. June 2025, AS Unit 1, Q5(b) (3 marks): Protein synthesis increases as a cell grows. Describe the roles of messenger RNA (mRNA) and transfer RNA (tRNA) in protein synthesis. (3)
  2. June 2025, AS Unit 1, Q5(c)(i) (2 marks): Give one advantage and one disadvantage of using a Voronoi diagram to present this information. (2) Advantage Disadvantage
  3. June 2025, AS Unit 1, Q5(c)(ii) (6 marks): The proportions of these molecules change as a bacterial cell prepares to divide, as it divides into two new bacterial cells and as each new bacterial cell grow
  4. June 2025, Unit 4, Q6(b)(iii) (4 marks): Describe the roles of the proteins: • RNA polymerase • ribosomal protein • RUBISCO • ATP synthetase. (4)
  5. January 2025, AS Unit 1, Q6(c)(iii) (2 marks): Another drug, used to treat FH, is a short antisense strand of DNA from the apo B gene. Suggest how this antisense strand of DNA would reduce the levels of apo
  6. January 2025, AS Unit 2, Q7(b)(iii) (1 mark): Which row gives the names of the molecules labelled X and Z? (1) Molecule X Molecule Z A polypeptide DNA strand B polypeptide RNA strand C polysaccharide DNA st
  7. October 2024, AS Unit 1, Q5(b)(i) (2 marks): Describe the role of mRNA in the production of enzymes. (2)
  8. June 2024, AS Unit 1, Q3(a) (2 marks): Describe the role of RNA polymerase in protein synthesis. (2)
  9. June 2024, AS Unit 1, Q3(b) (3 marks): Compare and contrast the structure of the start and stop codons and how they work. (3)
  10. June 2024, AS Unit 1, Q3(c) (2 marks): Describe the roles of the ribosomes in protein synthesis. (2)
  11. October 2023, AS Unit 1, Q3(a) (2 marks): The rate of protein synthesis is dependent on a number of factors. The graph shows the effect of the mass of protein in the diet on the rate of protein synthesi
  12. October 2023, AS Unit 1, Q3(b)(i) (1 mark): Name the two stages in protein synthesis, in the order that they occur. (1) Stage 1 Stage 2
  13. October 2023, AS Unit 1, Q3(b)(ii) (4 marks): Describe the roles of messenger RNA (mRNA) and transfer RNA (tRNA) in protein synthesis. (4)
  14. June 2023, AS Unit 1, Q1(a)(i) (1 mark): Complete the diagram to show the sequence of bases in this mRNA. (1)
  15. June 2023, AS Unit 1, Q1(a)(ii) (1 mark): Name this stage of protein synthesis. (1)
  16. June 2023, AS Unit 1, Q1(a)(iii) (1 mark): Name the enzyme used in this stage of protein synthesis. (1)
  17. January 2023, AS Unit 1, Q8(c)(i) (3 marks): Explain how the alleles present in individual 3 result in the proteins found on the surfaces of his red blood cells. (3)
  18. January 2023, Unit 4, Q8(a)(i) (3 marks): Describe how the viral RNA is translated. (3)
  19. October 2021, AS Unit 1, Q6(b)(iii) (3 marks): In AHP, toxic porphyrin molecules build up. The synthesis of the haem component of haemoglobin involves several steps. Each step in the synthesis of haem is cat
  20. October 2021, Unit 4, Q2(b)(ii) (2 marks): Explain why a positive RNA strand has to be made. (2)
  21. October 2021, Unit 5, Q6(a)(i) (1 mark): Which is the function of tRNA in cytokine synthesis? (1) A identifies an amino acid and transports it to a ribosome B identifies a base and transports it to a r
  22. January 2021, AS Unit 1, Q1(b)(i) (3 marks): The table shows some statements about the new complementary DNA strand and the mRNA strand synthesised using this sequence of bases. For each statement, put one
  23. January 2021, AS Unit 1, Q1(b)(ii) (1 mark): Name the process that synthesises a mRNA strand using the DNA template strand. (1)
  24. October 2020, AS Unit 1, Q1(a) (5 marks): Read through the following account of the primary structure of a protein. (5) Complete the account by writing the most appropriate word or words on the dotted l
  25. October 2020, AS Unit 1, Q6(b)(i) (1 mark): Give the sequence of amino acids that is coded for by these bases. (1)
  26. June 2019, AS Unit 1, Q3(d) (1 mark): Messenger RNA (mRNA) and transfer RNA (tRNA) are involved in the synthesis of a polypeptide chain from DNA. Which row of the table shows the codon on mRNA and t
  27. June 2019, AS Unit 1, Q8(b)(iii) (3 marks): Transfer RNA (tRNA) is involved in translation. The amino acid AzPhe requires a special tRNA molecule during the synthesis of silk. Suggest why AzPhe is not ins

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