plumiBlood clotting: Edexcel International A Level Biology questions
Edexcel International A Level Biology past-paper questions on 1.3.2 Blood clotting, 2019–2025, with mark schemes and examiner’s reports where available.
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All 29 questions on Blood clotting, as a list
- June 2025, AS Unit 1, Q1(a) (3 marks): Read through the following passage about prothrombin and the blood clotting process. Complete the passage by writing the most appropriate word or words on the d
- June 2025, AS Unit 1, Q1(c) (1 mark): The range for a healthy PT is between 10 and 13 seconds. A person with a PT of 8.5 seconds was treated with a drug to increase the PT time to 10 seconds. Calcul
- January 2025, AS Unit 1, Q3(a)(i) (1 mark): Which molecule, released from platelets, results in blood clotting? (1) A fibrinogen B prothrombin C thrombin D thromboplastin
- January 2025, AS Unit 1, Q3(a)(ii) (1 mark): Which pair of molecules are enzymes in their active form? (1) A fibrinogen and prothrombin B prothrombin and thrombin C thrombin and thromboplastin D thrombopla
- January 2025, AS Unit 1, Q3(a)(iii) (1 mark): Which molecule found in the blood is insoluble? (1) A fibrin B fibrinogen C prothrombin D thromboplastin
- January 2025, AS Unit 1, Q3(b) (3 marks): Pulmonary embolism can be caused by a DVT when the blood clot travels through the circulatory system and blocks the pulmonary artery. Symptoms of pulmonary embo
- January 2025, AS Unit 1, Q3(c) (3 marks): A study of bears in Sweden discovered that these bears produced less HSP47 protein when hibernating in the winter. This protein is found on platelets and is inv
- June 2024, AS Unit 1, Q5(c) (3 marks): In haemophilia, activation of the blood clotting pathway results in less thrombin being produced than in healthy individuals. Explain how reduced thrombin will
- June 2023, AS Unit 1, Q5(a) (2 marks): Explain how damage to the endothelial cells results in the formation of thrombin. (2)
- June 2023, AS Unit 1, Q5(c)(ii) (2 marks): Explain how variegin prevents blood clotting. (2)
- January 2023, Unit 4, Q8(b) (4 marks): Another group of scientists showed that an extract from the leaves of the papaya plant helped in recovery from dengue virus infection. They showed that the plat
- October 2022, AS Unit 1, Q6(a) (1 mark): How many of the following statements are correct for thromboplastin? • it is stored in platelets • it is an active enzyme • it is converted into thrombin (1) A
- October 2022, AS Unit 1, Q6(c) (3 marks): Explain how taking this anticoagulant can reduce the risk of cardiovascular disease (CVD). (3)
- June 2022, AS Unit 1, Q2(a) (1 mark): Which molecule traps red blood cells and platelets in the formation of a blood clot at a wound? (1) A cholesterol B collagen C fibrin D fibrinogen
- June 2022, AS Unit 1, Q2(b) (1 mark): How many of the following are converted into an active enzyme during blood clotting? • fibrin • fibrinogen • prothrombin • thrombin (1) A 1 B 2 C 3 D 4
- June 2022, AS Unit 1, Q2(c) (1 mark): How many of the following are soluble in blood plasma? • fibrin • fibrinogen • prothrombin • thrombin (1) A 1 B 2 C 3 D 4
- June 2022, AS Unit 1, Q2(d) (3 marks): Thromboplastin is stored inside platelets. Explain the advantages of storing thromboplastin inside platelets. (3)
- June 2022, Unit 6, Q2(c) (4 marks): Vitamin C is needed in the production of factors involved in the formation of a blood clot. Describe how a blood clot is formed. (4)
- October 2021, AS Unit 1, Q2(a)(i) (3 marks): Read through the following passage about warfarin. Write on the dotted lines the most appropriate word or words to complete the passage. (3) Warfarin is used to
- October 2021, AS Unit 1, Q2(b) (2 marks): The time taken for a blood sample to form a blood clot can be measured. This is called the clotting time. The graph shows the blood clotting time after a patien
- June 2021, AS Unit 1, Q3(b)(ii) (1 mark): State how the formation of a blood clot in the coronary artery could cause the death of the patient. (1)
- June 2021, AS Unit 1, Q3(b)(iii) (1 mark): Which components of the blood clotting process are enzymes in their active form? (1) A prothrombin and thromboplastin only B prothrombin and thrombin only C pro
- June 2021, AS Unit 1, Q3(b)(iv) (1 mark): Which components of the blood clotting process are soluble in blood plasma? (1) A fibrin and fibrinogen B fibrin and thromboplastin C fibrinogen and thromboplas
- October 2020, AS Unit 1, Q7(a) (3 marks): Describe the role of prothrombin in the blood clotting process. (3)
- June 2019, AS Unit 1, Q2(b)(i) (2 marks): One anticoagulant binds to the active site of thrombin. Explain how this drug reduces blood clotting. (2)
- June 2019, AS Unit 1, Q2(b)(ii) (2 marks): Molecules on the surface of platelets enable them to bind to other molecules. One of the antiplatelet drugs affects molecules on the surface of platelets. Expla
- June 2019, AS Unit 1, Q2(b)(iii) (2 marks): One thrombolytic drug converts plasminogen into the active enzyme, plasmin. Plasmin breaks down fibrin. Explain how this drug reduces the formation of blood clo
- January 2019, AS Unit 1, Q6(a)(iii) (4 marks): Describe how the movement of phosphatidylserine into the outer layer results in the production of thrombin in the blood clotting process. (4)
- January 2019, AS Unit 1, Q6(b) (4 marks): Thrombin inhibitors are drugs that have an effect on the time taken for blood to clot. Explain why thrombin inhibitors affect the time taken for blood to clot.
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