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Transcription factors and hormones: Edexcel International A Level Biology questions

Edexcel International A Level Biology past-paper questions on 7.5.1 Transcription factors and hormones, 2019–2025, with mark schemes and examiner’s reports where available.

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  1. Q7(a)(ii)

    June 2025 · Unit 5

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  2. The start of question 5

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  3. Q2(b)(i)

    October 2024 · Unit 5

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  4. Q2(b)(ii)

    October 2024 · Unit 5

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  6. Q8(c)

    January 2024 · Unit 5

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  7. Q1(b)

    October 2023 · Unit 5

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  8. Q4(c)

    January 2023 · Unit 5

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  9. Q8(d)

    January 2022 · Unit 5

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  10. Q6(c)

    October 2021 · Unit 5

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  11. Q8(g)

    June 2021 · Unit 5

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  12. Q7(b)(i)

    January 2021 · Unit 5

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All 12 questions on Transcription factors and hormones, as a list
  1. June 2025, Unit 5, Q7(a)(ii) (3 marks): Growth hormone is a peptide hormone that stimulates the synthesis of protein in muscle. Explain how GH stimulates the synthesis of protein in muscle. (3)
  2. January 2025, Unit 5, Q5(d)(i) (1 mark): Give one reason why there is no bar on the graph for an insulin concentration at 0 pmol dm–3. (1)
  3. October 2024, Unit 5, Q2(b)(i) (3 marks): Describe three conclusions that can be drawn from this investigation. (3)
  4. October 2024, Unit 5, Q2(b)(ii) (3 marks): Describe how steroid hormones regulate gene transcription. (3)
  5. October 2024, Unit 6, Q1(c) (3 marks): Describe how gibberellin increases amylase synthesis. (3)
  6. January 2024, Unit 5, Q8(c) (4 marks): Testosterone is a steroid hormone. Describe how reduced production of testosterone in the male testes can result in reduced muscle protein (paragraph 5). (4)
  7. October 2023, Unit 5, Q1(b) (3 marks): Describe how genes can be switched off by transcription factors. (3)
  8. January 2023, Unit 5, Q4(c) (4 marks): Oestrogen stimulates some types of breast cancer to proliferate. Oestrogen is a steroid hormone found in mammals. Oestrogen affects up to 100 different genes. E
  9. January 2022, Unit 5, Q8(d) (3 marks): Suggest how electrophilic species (ES) of free radicals could be “involved in the modulation of gene expression” (paragraph 6). (3)
  10. October 2021, Unit 5, Q6(c) (3 marks): Explain how cytokine genes can be expressed in an activated T lymphocyte. (3)
  11. June 2021, Unit 5, Q8(g) (2 marks): Suggest how myostatin might act as a negative regulator of muscle growth (paragraph 13). (2)
  12. January 2021, Unit 5, Q7(b)(i) (2 marks): Explain how transcription factors are involved in the synthesis of dopamine. (2)

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