What happens in cells (and what do cells need)?: OCR GCSE Biology A questions

Every OCR GCSE Biology A exam question on B1.2 What happens in cells (and what do cells need)?, 2018–2025, with its mark scheme and examiner’s report.

All 132 questions on What happens in cells (and what do cells need)?, as a list

June 2025, Paper 1 Foundation, Q5 (1 mark): A student tests a sample of milk to see if it contains sugar. Which reagent would the student use and what colour would be observed for a positive result? Colou
June 2025, Paper 1 Foundation, Q9 (1 mark): The enzyme protease is added to a sample of protein. What will increase in concentration? A Amino acids B Fatty acids C Glucose D Glycerol Your answer [1]
June 2025, Paper 1 Foundation, Q16(a) (2 marks): Complete the table to show which letter represents each part of DNA. Part of the DNA Letter Base Phosphate Sugar [2]
June 2025, Paper 1 Foundation, Q16(b) (3 marks): Which words can be used to describe DNA? Tick (✓) three boxes. Double helix Molecule Monomer Polymer Protein Single helix [3]
June 2025, Paper 1 Foundation, Q16(c) (3 marks): A sample of DNA is analysed. 15% of the bases in the sample are Adenine (A). Calculate the percentage of the bases that are Guanine (G). Percentage = % [3]
June 2025, Paper 1 Foundation, Q18(a) (1 mark): What monomers are large carbohydrates such as starch made from? [1]
June 2025, Paper 1 Foundation, Q18(b) (3 marks): Explain why the enzyme amylase cannot break down the substrate protein. Include ideas about the active site. [3]
June 2025, Paper 1 Foundation, Q18(c) (1 mark): Amylase is an enzyme that works best in alkaline conditions. State what will happen to the structure of the enzyme when it enters the acidic conditions of the s
June 2025, Paper 1 Foundation, Q18(d)(i) (2 marks): Describe how temperature affects the relative activity of this enzyme. [2]
June 2025, Paper 1 Foundation, Q18(d)(ii) (1 mark): Describe how this experiment could be improved to determine a more accurate optimum temperature for this enzyme. [1]
June 2025, Paper 3 Higher, Q5 (1 mark): Which of these biological molecules are polymers? A Amino acid and protein B DNA and glucose C DNA and protein D Glucose and protein Your answer [1]
June 2025, Paper 3 Higher, Q6 (1 mark): Which biological molecule does this diagram represent? A Glucose B Lipid C Protein D Starch Your answer [1]
June 2025, Paper 3 Higher, Q18(a) (1 mark): Draw a circle around one nucleotide on the diagram. [1]
June 2025, Paper 3 Higher, Q18(b) (5 marks): Complete the sentences to describe how DNA codes for the production of a protein. Use words from the list. amino acids chromosome fatty acids gene mitochondrion
June 2025, Paper 3 Higher, Q18(c) (2 marks): DNA molecules are found in both eukaryotic and prokaryotic cells. Describe the differences in the location and shape of the molecule in these two types of cell.
June 2025, Paper 3 Higher, Q20(a) (6 marks): Catalase is an enzyme that breaks down hydrogen peroxide into oxygen and water. When catalase is added to hydrogen peroxide in a test tube, the oxygen bubbles a
June 2025, Paper 3 Higher, Q20(b) (3 marks): Catalase is found in the human body. Fig. 20.2 shows the effect of pH on the rate of activity of human catalase. Fig. 20.2 Rate of activity pH 1 2 3 4 5 6 7 8 9
June 2025, Paper 3 Higher, Q20(c) (3 marks): Explain why catalase can only break down hydrogen peroxide. [3]
June 2024, Paper 1 Foundation, Q13 (1 mark): The diagram shows the order of bases in one strand of DNA. T C A G G A C What is the base sequence of the complementary strand of DNA? A A G T C C T G B C T G A
June 2024, Paper 1 Foundation, Q14 (1 mark): Cellulose is a complex carbohydrate. Which monomers is cellulose made from? A Amino acids B Fatty acids C Glycerol D Simple sugars Your answer [1]
June 2024, Paper 1 Foundation, Q18(a) (2 marks): The developing chick gets most of its nutrition from the egg yolk. A student tests the yolk for protein. The tables show: • reagents that could be used to test
June 2024, Paper 2 Foundation, Q22(c)(i) (1 mark): The graph shows the pattern of the students’ results for 15 °C and 35 °C. Draw a line on the graph to show the pattern at 25 °C. 15 °C pH of the milk 35 °C Time
June 2024, Paper 2 Foundation, Q22(c)(ii) (4 marks): Complete the sentences to explain the difference between the students’ results at 15 °C and 35 °C. Milk decomposes at 35 °C. Increasing the temperature increase
June 2024, Paper 2 Foundation, Q22(c)(iii) (2 marks): The students want to find the temperature at which the enzymes from the microorganisms change shape and stop functioning (denature). How could they extend their
June 2024, Paper 3 Higher, Q1 (1 mark): Cellulose is a complex carbohydrate. Which monomers is cellulose made from? A Amino acids B Fatty acids C Glycerol D Simple sugars Your answer [1]
June 2024, Paper 3 Higher, Q6 (1 mark): A section of DNA is analysed to find the percentage of each of the four bases present. 16% of the DNA is guanine. What is the percentage of the other bases in t
June 2024, Paper 3 Higher, Q7 (1 mark): Which statement about DNA is correct? A DNA codes for the production of amino acids. B DNA contains specific sequences of amino acids and bases. C DNA is a poly
June 2024, Paper 3 Higher, Q24(a) (6 marks): Glycogen storage disease is caused by a mutation in the DNA that codes for an enzyme (a protein) that converts glycogen into glucose. The mutation changes the t
June 2024, Paper 3 Higher, Q24(b) (3 marks): Glucose is often found in the urine of people who have diabetes. Benedict’s solution is used to detect glucose in the urine. It is also used to give a measure o
June 2024, Paper 4 Higher, Q20(c) (3 marks): Explain the effect of increasing the temperature on the decomposition of the milk in the experiment. [3]
June 2024, Paper 4 Higher, Q20(d) (2 marks): The students plan a further experiment where they boil the milk first before placing it in the beaker. Predict what effect this would have on the results. Expla
June 2024, Paper 4 Higher, Q21(c)(i) (4 marks): Complete these sentences about how genes are expressed. Use words from the list. coding DNA denaturing non-coding DNA nucleus ribosomes transcription translatio
June 2023, Paper 1 Foundation, Q16(a) (3 marks): Put ticks in the table to show whether each statement is true or false about the structure of DNA. Tick (✓) one box in each row. Statement about DNA True False
June 2023, Paper 1 Foundation, Q19(a)(i) (2 marks): Plot a graph of the results. [2]
June 2023, Paper 1 Foundation, Q19(a)(ii) (1 mark): Draw a line of best fit. [1] 30 25 20 Volume of oxygen 15 collected (cm3) 10 5 0 0 1 2 3 4 5 6 7 8 9 10 pH
June 2023, Paper 1 Foundation, Q19(b) (2 marks): Write down a conclusion for the student’s results. Include data in your answer. [2]
June 2023, Paper 1 Foundation, Q19(c) (2 marks): When collecting data, it is important that it is accurate, valid and repeatable. Draw lines to link each improvement the student could make to the effect this i
June 2023, Paper 1 Foundation, Q19(d) (1 mark): The student wants to increase their confidence in finding the correct optimum pH for catalase. What should the student do? Tick (✓) one box. Repeat the experime
June 2023, Paper 1 Foundation, Q21(a) (5 marks): To try to lose weight some people go on a type of diet called a ketogenic diet. In a ketogenic diet, a person eats food that is high in fat and protein but low
June 2023, Paper 1 Foundation, Q21(b) (3 marks): Three people each make a comment about this diet. Person A: People who are very overweight could lose weight if they went on this diet and this may make them fe
June 2023, Paper 1 Foundation, Q21(c) (2 marks): A class is discussing how to test food to see if it contains carbohydrates. A student says ‘You need to do two different named tests to see if carbohydrates are
June 2023, Paper 2 Foundation, Q20(b)(iv) (2 marks): The student concluded that acid pollution slows the rate of duckweed reproduction. Explain how acid pollution slows the rate of duckweed reproduction. Use ideas
June 2023, Paper 3 Higher, Q8 (1 mark): In an enzyme experiment, a student tries to measure pH by dipping universal indicator paper into a solution. They then use a pH chart in their textbook. They fi
June 2023, Paper 3 Higher, Q12 (1 mark): In a keto diet, people eat foods that consist mainly of proteins and lipids. What will they lack in their diet? A Amino acids, fatty acids and glucose B Glucose
June 2023, Paper 3 Higher, Q13 (1 mark): Which molecules are all polymers? A DNA, amino acids and starch B Fatty acids, glycerol and amino acids C RNA, glucose and fatty acids D Starch, protein and DNA
June 2023, Paper 3 Higher, Q18(c) (2 marks): Nephritis is a condition where part of the kidney tubule becomes inflamed. The result of this is that proteins can enter the tubule and pass out in the urine. D
June 2023, Paper 3 Higher, Q20(a) (4 marks): Explain why the jelly made with fresh pineapple does not set but the jelly made with tinned pineapple does set. Use your knowledge of enzymes. [4]
June 2023, Paper 3 Higher, Q20(b) (2 marks): The graph shows the rate of an enzyme catalysed reaction as the concentration of substrate is changed. Initial rate of reaction Substrate concentration Draw an
June 2023, Paper 3 Higher, Q24(a) (6 marks): * Beta thalassaemia is a genetic disorder caused by a mutation in DNA. In this mutation, some bases are inserted into the gene that codes for the production of
June 2022, Paper 1 Foundation, Q1 (1 mark): What does one DNA nucleotide consist of? A A phosphate and sugar backbone B A sugar, a phosphate and a base C Four bases, A, C, T and G D Two different sugars a
June 2022, Paper 1 Foundation, Q6 (1 mark): What word describes the amino acids that join to make a protein molecule? A Enzymes B Monomers C Nucleotides D Polymers Your answer [1]
June 2022, Paper 1 Foundation, Q8 (1 mark): DNA consists of two strands. This is the base sequence found in one strand: ATT Which is the complementary base sequence of the second strand? A ATT B CAG C CGG
June 2022, Paper 1 Foundation, Q9 (1 mark): One symptom of diabetes is glucose in the urine. Which biochemical test is used to confirm the presence of glucose in the urine? A Benedict’s B Biuret C Ethanol
June 2022, Paper 1 Foundation, Q13 (1 mark): The diagram shows the lock and key hypothesis of how enzymes work. B D A C Which letter, A, B, C or D represents the active site of the enzyme? [1] Your answer
June 2022, Paper 1 Foundation, Q23(a)(i) (3 marks): Complete the labels in Fig. 23.1. [3]
June 2022, Paper 1 Foundation, Q23(a)(ii) (2 marks): Lipase is found in the small intestine where the pH is alkaline. Draw a curve on Fig. 23.2 to show the effect the pH will have on the rate of reaction for the d
June 2022, Paper 1 Foundation, Q23(b) (5 marks): Phenolphthalein is an indicator that turns pink in an alkaline solution of pH 10. When lipase breaks down lipids, the indicator goes colourless. A group of stud
June 2022, Paper 3 Higher, Q12 (1 mark): In a sample of DNA, 37% of the bases are thymine (T). What will be the percentage of the other bases in this sample? A Adenine (A) 13%, Cytosine (C) 13%, Guanin
June 2022, Paper 3 Higher, Q16(a)(i) (3 marks): Complete the labels in Fig. 16.1. [3]
June 2022, Paper 3 Higher, Q16(a)(ii) (2 marks): Lipase is found in the small intestine where the pH is alkaline. Draw a curve on Fig. 16.2 to show the effect the pH will have on the rate of reaction for the d
June 2022, Paper 3 Higher, Q16(b) (5 marks): Phenolphthalein is an indicator that turns pink in an alkaline solution of pH 10. When lipase breaks down lipids, the indicator goes colourless. A group of stud
June 2022, Paper 3 Higher, Q21(b)(i) (2 marks): Describe one biochemical test that can be used to test for the presence of glucose. [2]
June 2022, Paper 3 Higher, Q21(b)(ii) (1 mark): Suggest how this test could be used to compare how much glucose is present in two different tissues. [1]
June 2022, Paper 3 Higher, Q23(a) (2 marks): The statements A–E describe parts of the process of protein synthesis. They are not in the correct order. A A copy of DNA is formed during transcription; this i
June 2022, Paper 3 Higher, Q23(b) (2 marks): Describe how the triplet code determines the structure of a protein. [2]
June 2022, Paper 3 Higher, Q23(c)(i) (2 marks): Use the diagram to explain how changing the order of the sections would produce a different protein. [2]
June 2022, Paper 3 Higher, Q23(c)(ii) (1 mark): Write down how many different proteins could be made from the three sections of RNA. Number of proteins = [1]
June 2022, Paper 4 Higher, Q19(d) (2 marks): Scientists are now developing a new treatment called gene silencing. They have developed a drug that destroys the mRNA that codes for the amyloid protein. Expla
November 2021, Paper 1 Foundation, Q1 (1 mark): Base pairs are found in a molecule of DNA. Which base pairs with cytosine? A Adenine (A) B Cytosine (C) C Guanine (G) D Thymine (T) Your answer [1]
November 2021, Paper 1 Foundation, Q10 (1 mark): Which molecule is joined to fatty acids to make a lipid? A Amino acid B Glucose C Glycerol D Starch Your answer [1]
November 2021, Paper 1 Foundation, Q15 (1 mark): Q10 is a measure of the rate of change of a reaction when temperature is increased by 10°C. Q10 is calculated using this formula: Q10 = rate at higher temperatu
November 2021, Paper 1 Foundation, Q16(b)(v) (2 marks): The cell wall in the plant cell is made from a carbohydrate called cellulose. Cellulose is a polymer. Explain why sugars are needed to make the cell wall. [2]
November 2021, Paper 1 Foundation, Q18(a)(ii) (1 mark): DNA replication produces a new DNA molecule. What name describes the shape of a DNA molecule? [1]
November 2021, Paper 2 Foundation, Q23(a) (2 marks): Photosynthesis is controlled by enzymes. Which two statements explain how an acid could affect photosynthesis? Tick (3) two boxes. Acid will decrease the pH and
November 2021, Paper 3 Higher, Q2 (1 mark): Q10 is a measure of the rate of change of a reaction when temperature is increased by 10 °C. Q10 is calculated using this formula: Q10 = rate at higher temperat
November 2021, Paper 3 Higher, Q5 (1 mark): Which statement describes why iodine solution is added to onion epidermis cells before viewing under a microscope? A To colour any protein in the cell. B To kil
November 2021, Paper 3 Higher, Q7 (1 mark): Which statement describes DNA? A A monomer of one strand that forms a single helix. B A monomer of two strands that form a double helix. C A polymer of two stra
November 2021, Paper 3 Higher, Q21(b)(i) (3 marks): Identify three problems with using the information in Table 21.1 to estimate the concentration of glucose in a food. 1 2 3 [3]
November 2021, Paper 3 Higher, Q21(b)(ii) (2 marks): Suggest two ways to improve this method so that the colour change of Benedict’s solution can give a more accurate estimate of glucose concentration. 1 2 [2]
November 2021, Paper 3 Higher, Q21(c) (2 marks): Instead of measuring colour change, a precipitate can be collected. The precipitate is dried and its mass is measured. The concentration of glucose can then be
November 2021, Paper 3 Higher, Q22(b) (6 marks): (b)* Actinomycin D is a drug used in experiments investigating control of growth of malignant tumours. The drug inhibits one stage of protein synthesis. The dru
November 2021, Paper 3 Higher, Q22(c) (2 marks): Explain how the structure of DNA determines the type of protein made. [2]
November 2021, Paper 4 Higher, Q17(a) (2 marks): Photosynthesis is controlled by enzymes. Which two statements explain how an acid could affect photosynthesis? Tick (3) two boxes. Acid will decrease the pH and
November 2020, Paper 1 Foundation, Q4 (1 mark): Which monomer is used to make proteins? A Amino acid B Fatty acid C Glucose D Glycerol Your answer [1]
November 2020, Paper 1 Foundation, Q16(c)(i) (1 mark): Why did the students use four different colours of round sweets in their model of DNA? [1]
November 2020, Paper 1 Foundation, Q16(c)(ii) (2 marks): Write down the names of the two types of chemical group represented by the candy laces. 1 2 [2]
November 2020, Paper 1 Foundation, Q17(a)(i) (1 mark): What other way could be used to keep the flask at a constant temperature? [1]
November 2020, Paper 1 Foundation, Q17(a)(ii) (1 mark): She chooses to use a Bunsen burner and water bath. Give one safety precaution she should take. [1]
November 2020, Paper 1 Foundation, Q17(a)(iii) (2 marks): Explain why using a Bunsen burner and water bath may introduce errors into her results. [2]
November 2020, Paper 1 Foundation, Q17(b)(i) (2 marks): Calculate the mean for the results at 30 °C and complete the table. [2]
November 2020, Paper 1 Foundation, Q17(b)(ii) (1 mark): The student repeated the experiment at two more temperatures, 20 °C and 35 °C, to get enough readings to plot a line graph. Which measurement should the student
November 2020, Paper 1 Foundation, Q17(b)(iii) (1 mark): Describe one way that the range would improve any conclusions made from the graph. [1]
November 2020, Paper 1 Foundation, Q17(b)(iv) (2 marks): The mean volume at a temperature of 20 °C was 15 cm3 and for a temperature of 35 °C it was 27 cm3. Describe what the student’s results show about the effect of
November 2020, Paper 1 Foundation, Q20(b) (2 marks): The skin on some areas of the body contains hairs. Modern hair shampoos contain cleaning agents. One cleaning agent is made from fatty acids. Explain how a poly
November 2020, Paper 1 Foundation, Q20(c)(i) (2 marks): The skin is important for controlling body temperature. Explain why overheating of the body may stop chemical reactions in cells. [2]
November 2020, Paper 2 Foundation, Q16(c)(i) (3 marks): Describe how you could test some stevia leaves to prove that they do not contain sugar. Reagent used Method Expected result [3]
November 2020, Paper 3 Higher, Q8 (1 mark): In a sample of DNA, 23% of the bases are cytosine. What percentage of the bases are adenine? A 23% B 27% C 46% D 54% Your answer [1]
November 2020, Paper 3 Higher, Q18(a) (1 mark): The student could have measured the volume of carbon dioxide by collecting the gas over water in a measuring cylinder. Why is it better to use a gas syringe? [1
November 2020, Paper 3 Higher, Q18(b)(i) (3 marks): Calculate the mean rate of gas produced at 25 °C in cm3 / minute. Give your answer to 1 decimal place. Mean rate of gas produced at 25 °C = cm3 / minute [3]
November 2020, Paper 3 Higher, Q18(b)(ii) (3 marks): The rate of gas produced at 30 °C is greater than at 25 °C. Use ideas about enzymes to explain why. [3]
November 2020, Paper 3 Higher, Q18(c) (2 marks): Phenols are chemicals that inhibit enzymes during fermentation. They bind to amino acids on enzyme molecules. Suggest how phenols inhibit enzymes. [2]
November 2020, Paper 3 Higher, Q22(a) (4 marks): Describe what happens during protein synthesis. Use terms from the list in your answer. amino acids DNA mRNA transcription translation ribosome [4]
November 2020, Paper 3 Higher, Q22(b)(i) (2 marks): Complete the sentences to explain the link between amino acids and proteins. Large molecules, like proteins, made of smaller molecules are called The smaller mo
November 2020, Paper 4 Higher, Q21(d) (2 marks): The allele that is affected by HC codes for a protein called LDL receptor protein. The faulty allele often has four extra nucleotides, making a total of 2521 nu
June 2019, Paper 1 Foundation, Q2 (1 mark): How many different bases are in DNA? A 2 B 4 C 23 D 46 Your answer [1]
June 2019, Paper 1 Foundation, Q12 (1 mark): When the enzyme lipase is mixed with a lipid which of the following will increase in concentration? A Amino acids B Fatty acids and glycerol C Glucose and fruct
June 2019, Paper 1 Foundation, Q20(c) (2 marks): Drugs can be used to treat one type of diabetes. One drug prevents an enzyme working properly. Suggest how a drug can stop an enzyme working. [2]
June 2019, Paper 3 Higher, Q3 (1 mark): Which structure most closely resembles DNA? A B C D Your answer [1]
June 2019, Paper 3 Higher, Q4 (1 mark): Look at the model of enzyme activity. B C A D Which label represents the active site of an enzyme? Your answer [1]
June 2019, Paper 3 Higher, Q5 (1 mark): Which biological molecule is not a polymer? A Amylase B DNA C Nucleotide D Starch Your answer [1]
June 2019, Paper 3 Higher, Q8 (1 mark): The diagram shows positive results in two different food tests. Tube 1 Tube 2 Food sample plus reagent: Treatment : shake boil in water-bath thoroughly for 3 mi
June 2019, Paper 3 Higher, Q22(a)(i) (2 marks): Describe the role of the DNA template and mRNA nucleotides in the production of the protein. [2]
June 2019, Paper 3 Higher, Q22(a)(ii) (2 marks): Describe the role of the tRNA nucleotides and ribosomes in the production of the protein. [2]
June 2019, Paper 3 Higher, Q22(b)(i) (2 marks): Many crimes committed over 30 years ago can now be solved using PCR. Explain why. [2]
June 2019, Paper 4 Higher, Q15 (1 mark): Gene 1 and gene 2 are both needed for the production of protein A. gene 1 gene 2 transcription translation protein A What is the function of gene 1 in this proc
June 2019, Paper 4 Higher, Q21(c) (2 marks): A new study is giving hope for a treatment for Huntington’s disease. Doctors gave patients an injection of a drug that blocks the action of mRNA that is produce
June 2018, Paper 1 Foundation, Q3 (1 mark): DNA is a polymer. What is the name of the monomer in DNA? A Base B Deoxyribose sugar C Nucleotide D Phosphate Your answer [1]
June 2018, Paper 1 Foundation, Q8 (1 mark): DNA is made of two complementary strands. The diagram shows part of one strand of DNA. P T P G P A Which base sequence would be found on the complementary stran
June 2018, Paper 1 Foundation, Q10 (1 mark): A student wants to test for protein. What would they use to test for protein? A Benedict’s reagent B Biuret reagent C Iodine solution D Ethanol Your answer [1]
June 2018, Paper 1 Foundation, Q21(a) (2 marks): One group of students made a water bath using a beaker of water, thermometer and Bunsen burner. Another group used an electric water bath. Write down two advant
June 2018, Paper 1 Foundation, Q21(b) (2 marks): Low temperatures protect DNA by slowing down the activity of enzymes that destroy DNA. High temperatures break down membranes in the cell. To extract DNA, some
June 2018, Paper 1 Foundation, Q21(c) (2 marks): Suggest two safety precautions which should be taken at stage 2. Explain why each safety precaution is needed. 1 Safety precaution: Explanation: 2 Safety precau
June 2018, Paper 1 Foundation, Q21(d)(i) (2 marks): Calculate the mean mass collected in the investigation using the electric water bath. Give your answer to 1 decimal place. Answer = mg [2]
June 2018, Paper 1 Foundation, Q21(d)(ii) (2 marks): The range of the three test readings for the beaker of water and Bunsen burner was 3.4. Does the evidence support using an electric water bath instead of a beak
June 2018, Paper 3 Higher, Q3 (1 mark): During protein synthesis the DNA that codes for a particular protein is copied. This copy is called mRNA. The diagram below shows the base sequence for a sectio
June 2018, Paper 3 Higher, Q16(a) (2 marks): One group of students made a water bath using a beaker of water, thermometer and Bunsen burner. Another group used an electric water bath. Write down two advant
June 2018, Paper 3 Higher, Q16(b) (2 marks): Low temperatures protect DNA by slowing down the activity of enzymes that destroy DNA. High temperatures break down membranes in the cell. To extract DNA, some
June 2018, Paper 3 Higher, Q16(c) (2 marks): Suggest two safety precautions which should be taken at stage 2. Explain why each safety precaution is needed. 1 Safety precaution: Explanation: 2 Safety precau
June 2018, Paper 3 Higher, Q16(d)(i) (2 marks): Calculate the mean mass collected in the investigation using the electric water bath. Give your answer to 1 decimal place. Answer = mg [2]
June 2018, Paper 3 Higher, Q16(d)(ii) (2 marks): The range of the three test readings for the beaker of water and Bunsen burner was 3.4. Does the evidence support using an electric water bath instead of a beak
June 2018, Paper 3 Higher, Q20(d)(iv) (2 marks): Infertility can also be caused by problems in the male. Plasmin is a protease enzyme important in sperm movement. Explain how changes to the structure of DNA co
June 2018, Paper 4 Higher, Q23(c)(i) (2 marks): Explain why making more mRNA will switch off the mechanism faster. [2]

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