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Action potentials: Edexcel International A Level Biology questions

Edexcel International A Level Biology past-paper questions on 8.1.3 Action potentials, 2019–2025, with mark schemes and examiner’s reports where available.

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  1. Q3(c)

    June 2025 · Unit 5

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  2. Q4(a)

    January 2025 · Unit 5

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  3. Q4(b)

    January 2025 · Unit 5

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  4. Q4(c)

    January 2025 · Unit 5

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  5. Q4(d)(i)

    January 2025 · Unit 5

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  6. Q1(b)(i)

    October 2024 · Unit 5

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  7. Q1(b)(ii)

    October 2024 · Unit 5

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  8. Q1(b)(iii)

    October 2024 · Unit 5

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  9. Q5(c)(ii)

    June 2024 · Unit 5

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  10. Q2(a)(i)

    January 2024 · Unit 5

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  11. Q2(a)(ii)

    January 2024 · Unit 5

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  12. Q3(a)(i)

    January 2023 · Unit 5

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  13. Q3(a)(ii)

    January 2023 · Unit 5

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  14. Q8(c)

    October 2022 · Unit 5

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  15. Q8(d)

    October 2022 · Unit 5

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  16. Q6(b)

    January 2022 · Unit 5

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  17. Q2(b)(i)

    June 2021 · Unit 5

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  18. Q2(b)(ii)

    June 2021 · Unit 5

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  19. Q2(b)(iii)

    June 2021 · Unit 5

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  20. Q1(a)(i)

    January 2021 · Unit 5

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All 26 questions on Action potentials, as a list
  1. June 2025, Unit 5, Q3(c) (3 marks): The photograph shows a puffer fish. (Source: © ImageBROKER on Offset / Shutterstock) Tetrodotoxin (TTX) is a toxin found in puffer fish. This toxin works by bin
  2. January 2025, Unit 5, Q4(a) (4 marks): Describe how an action potential is produced in an axon. (4)
  3. January 2025, Unit 5, Q4(b) (2 marks): Axon membranes are permeable to potassium ions. The graph shows the permeability of an axon membrane to potassium ions after the start of an action potential. 2
  4. January 2025, Unit 5, Q4(c) (1 mark): The resting potential in a neurone is the result of the difference in concentration of ions on the outside and inside of the axon when no impulse is being trans
  5. January 2025, Unit 5, Q4(d)(i) (2 marks): Explain the effect of an increase in temperature on the speed of a nerve impulse along an axon. (2)
  6. October 2024, Unit 5, Q1(b)(i) (1 mark): Which is the resting potential for this neurone? (1) A –90 mV B –70 mV C +48 mV D +70 mV
  7. October 2024, Unit 5, Q1(b)(ii) (1 mark): Which letter on the graph shows where the neurone is hyperpolarised? (1) A U B V C W D X
  8. October 2024, Unit 5, Q1(b)(iii) (1 mark): Which is the difference in membrane potential between points V and W on the graph? (1) A 40 mV B 50 mV C 90 mV D 140 mV
  9. June 2024, Unit 5, Q5(c)(ii) (3 marks): A different neurotoxin called tetrodotoxin inhibits the transmission of nerve impulses along axons. In an experiment, axons of motor neurones were stimulated in
  10. January 2024, Unit 5, Q2(a)(i) (1 mark): Which row shows the events that happen during depolarisation of a neurone? (1) Sodium channels Membrane potential A closed decreasing B closed increasing C open
  11. January 2024, Unit 5, Q2(a)(ii) (3 marks): Explain what happens during repolarisation in a neurone. (3)
  12. January 2023, Unit 5, Q3(a)(i) (1 mark): Which description of the movement of ions will produce an action potential in an axon? (1) A K+ ions move into the axon B K+ ions move out of the axon C Na+ ion
  13. January 2023, Unit 5, Q3(a)(ii) (1 mark): Which row describes the events that occur during repolarisation of a neurone? (1) Sodium ion channel Membrane potential A closed decreasing B open decreasing C
  14. October 2022, Unit 5, Q8(c) (3 marks): Explain how capsaicin could activate nerve cells causing a pain sensation (paragraph 4). (3)
  15. October 2022, Unit 5, Q8(d) (3 marks): Explain how changes in ion channel protein can result in nerve impulses in the nervous system (paragraph 5). (3)
  16. January 2022, Unit 5, Q6(b) (2 marks): The diagram shows the change in membrane potential as an action potential is transmitted in a motor neurone. 30 0 membrane 2 potential / mV –55 1 –70 3 time Exp
  17. June 2021, Unit 5, Q2(b)(i) (3 marks): Describe how the resting potential of −70mV is maintained in the axon when no pressure is applied. (3)
  18. June 2021, Unit 5, Q2(b)(ii) (3 marks): Suggest how a change in pressure at the Pacinian corpuscle causes an action potential in the axon. (3)
  19. June 2021, Unit 5, Q2(b)(iii) (3 marks): Explain why the membrane potential at electrode Y was the same when medium or high pressure was applied to the fingertip. (3)
  20. January 2021, Unit 5, Q1(a)(i) (1 mark): Which is the resting potential for this axon? (1) A –70 mV B –78 mV C 38 mV D 108 mV
  21. January 2021, Unit 5, Q1(a)(ii) (1 mark): Both voltage-gated sodium and voltage-gated potassium ion channels are involved in generating an action potential. Which of these voltage-gated channels are ope
  22. January 2021, Unit 5, Q1(a)(iii) (1 mark): Which is the state of polarisation of the membrane at Z? (1) A depolarised B hyperpolarised C hypopolarised D unpolarised
  23. January 2021, Unit 5, Q1(a)(iv) (1 mark): How many of the following statements are correct?  the magnitude of the action potential is proportional to the strength of stimulus that generates the action
  24. January 2021, Unit 5, Q1(b) (3 marks): Explain why maintaining a resting potential requires ATP. (3)
  25. October 2020, Unit 5, Q6(b) (4 marks): Describe the role of ion transport in maintaining the resting potential of a neurone. (4)
  26. October 2020, Unit 5, Q6(c) (3 marks): The pufferfish produces a neurotoxin called tetrodotoxin (TTX). The graph shows the effect of TTX on the nerve impulse in an axon. +50 Membrane 0 untreated axon

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