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The immune system and immunisation: Edexcel GCSE Combined Science questions

Every Edexcel GCSE Combined Science exam question on The immune system and immunisation (specification points 5.12–5.14), 2018–2025, with its mark scheme and examiner’s report.

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2,937 questions

  1. Q4(b)

    June 2025 · Biology Paper 1 Higher

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  2. Q1(a)

    June 2025 · Biology Paper 2 Higher

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  3. Q5(b)

    June 2025 · Biology Paper 2 Foundation

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  4. Q2(b)

    June 2024 · Biology Paper 1 Higher

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  5. Q2(c)

    June 2024 · Biology Paper 1 Higher

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  6. Q1(b)

    June 2024 · Biology Paper 1 Foundation

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  7. Q6(b)

    June 2024 · Biology Paper 1 Foundation

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  8. Q6(c)

    June 2024 · Biology Paper 1 Foundation

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  9. Q6(b)

    June 2022 · Biology Paper 1 Foundation

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  10. Q6(c)

    November 2021 · Biology Paper 1 Foundation

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  11. Q6(a)(ii)

    November 2021 · Biology Paper 2 Foundation

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  12. Q1(b)

    November 2020 · Biology Paper 1 Higher

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  13. Q1(c)(iii)

    November 2020 · Biology Paper 1 Higher

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  14. Q5(c)

    November 2020 · Biology Paper 1 Foundation

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  15. Q5(d)(iii)

    November 2020 · Biology Paper 1 Foundation

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  16. Q2(a)

    June 2019 · Biology Paper 1 Higher

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  17. Q6(a)

    June 2019 · Biology Paper 1 Foundation

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  18. Q3(c)

    June 2018 · Biology Paper 1 Higher

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All 18 questions on The immune system and immunisation, as a list
  1. June 2025, Biology Paper 1 Higher, Q4(b) (3 marks): Describe the specific immune response when a pathogen infects the body. (3)
  2. June 2025, Biology Paper 2 Higher, Q1(a) (2 marks): Figure 1 shows a diagram of mucus‑producing goblet cells and ciliated epithelial cells in the airways of the lungs. ciliated epithelial mucus-producing cell gob
  3. June 2025, Biology Paper 2 Foundation, Q5(b) (2 marks): Figure 9 shows a diagram of mucus‑producing goblet cells and ciliated epithelial cells in the airways of the lungs. ciliated epithelial mucus-producing cell gob
  4. June 2024, Biology Paper 1 Higher, Q2(b) (2 marks): Measles is a disease caused by a virus. Figure 2 shows the number of measles cases reported in England and Wales from 1985 to 2015. year number of measles cases
  5. June 2024, Biology Paper 1 Higher, Q2(c) (2 marks): Describe two ways the immune system will respond to an infection by a pathogen. (2) 1 2
  6. June 2024, Biology Paper 1 Foundation, Q1(b) (2 marks): The human body has defences to protect against infection by bacteria. Draw one straight line from each body defence to its function. (2) body defence function m
  7. June 2024, Biology Paper 1 Foundation, Q6(b) (2 marks): Measles is a disease caused by a virus. Figure 9 shows the number of measles cases reported in England and Wales from 1985 to 2015. year number of measles cases
  8. June 2024, Biology Paper 1 Foundation, Q6(c) (2 marks): Describe two ways the immune system will respond to an infection by a pathogen. (2) 1 2
  9. June 2022, Biology Paper 1 Foundation, Q6(b) (6 marks): When a person is infected with a disease, the immune system will respond to protect their body. Explain how the immune system will respond to an infection cause
  10. November 2021, Biology Paper 1 Foundation, Q6(c) (6 marks): Describe how the physical barriers and chemical defences of the human body provide protection from diseases. (6)
  11. November 2021, Biology Paper 2 Foundation, Q6(a)(ii) (1 mark): State the function of the ciliated epithelial cells in the airways of the human breathing system. (1)
  12. November 2020, Biology Paper 1 Higher, Q1(b) (3 marks): Describe how the specific immune system defends the body against disease. (3)
  13. November 2020, Biology Paper 1 Higher, Q1(c)(iii) (1 mark): Give one reason why the number of people per million diagnosed with measles is different in these countries. (1)
  14. November 2020, Biology Paper 1 Foundation, Q5(c) (3 marks): Describe how the specific immune system defends the body against disease. (3)
  15. November 2020, Biology Paper 1 Foundation, Q5(d)(iii) (1 mark): Give one reason why the number of people per million diagnosed with measles is different in these countries. (1)
  16. June 2019, Biology Paper 1 Higher, Q2(a) (3 marks): Clostridium tetani is a bacterium that can be found in soil. It causes the infection tetanus. Children are vaccinated against tetanus. Explain why these childre
  17. June 2019, Biology Paper 1 Foundation, Q6(a) (3 marks): Clostridium tetani is a bacterium that can be found in soil. It causes the infection tetanus. Children are vaccinated against tetanus. Explain why these childre
  18. June 2018, Biology Paper 1 Higher, Q3(c) (3 marks): Most cases of scarlet fever occur in children. Adults have usually developed immunity to a toxin that the Streptococcus bacteria produce during infection. Expla

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