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Inheritance and genetic diagrams: Edexcel GCSE Combined Science questions

Every Edexcel GCSE Combined Science exam question on Inheritance and genetic diagrams (specification points 3.12–3.16), 2018–2025, with its mark scheme and examiner’s report.

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2,937 questions

  1. Q6(a)(i)

    June 2025 · Biology Paper 1 Higher

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  2. Q6(a)(ii)

    June 2025 · Biology Paper 1 Higher

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  3. Q6(b)

    June 2025 · Biology Paper 1 Higher

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  4. Q4(c)

    June 2023 · Biology Paper 1 Higher

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  5. Q4(a)

    June 2023 · Biology Paper 1 Foundation

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  6. Q4(b)(i)

    June 2023 · Biology Paper 1 Foundation

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  7. Q4(b)(ii)

    June 2023 · Biology Paper 1 Foundation

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  8. Q4(c)(i)

    June 2023 · Biology Paper 1 Foundation

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  9. Q4(c)(ii)

    June 2023 · Biology Paper 1 Foundation

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  10. Q5(a)(ii)

    June 2023 · Biology Paper 1 Foundation

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  11. Q3(c)(ii)

    June 2022 · Biology Paper 1 Foundation

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  12. Q3(c)(iii)

    June 2022 · Biology Paper 1 Foundation

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  13. Q4(b)(ii)

    November 2021 · Biology Paper 1 Higher

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  14. Q2(a)(i)

    November 2021 · Biology Paper 1 Foundation

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  15. Q2(a)(ii)

    November 2021 · Biology Paper 1 Foundation

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  16. Q2(a)(iii)

    November 2021 · Biology Paper 1 Foundation

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  17. Q3(a)

    November 2021 · Biology Paper 1 Foundation

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  18. Q4(a)(ii)

    June 2019 · Biology Paper 1 Foundation

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  19. Q4(a)(iii)

    June 2019 · Biology Paper 1 Foundation

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  20. Q4(a)(iv)

    June 2019 · Biology Paper 1 Foundation

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All 20 questions on Inheritance and genetic diagrams, as a list
  1. June 2025, Biology Paper 1 Higher, Q6(a)(i) (1 mark): Which row is correct for the mother, father and son? (1) mother father son A affected unaffected carrier B carrier affected affected C carrier affected carrier
  2. June 2025, Biology Paper 1 Higher, Q6(a)(ii) (2 marks): Cystic fibrosis causes the build‑up of thick, sticky mucus. Describe how the build-up of thick, sticky mucus affects the airways of a person. (2)
  3. June 2025, Biology Paper 1 Higher, Q6(b) (4 marks): Huntington’s disease is a condition caused by a dominant allele. Explain the phenotypes of the offspring of a genetic cross between a person who is heterozygous
  4. June 2023, Biology Paper 1 Higher, Q4(c) (2 marks): Sex determination in birds is different from humans. Males are homozygous Z and females are heterozygous ZW. Complete the Punnett square to show how sex is dete
  5. June 2023, Biology Paper 1 Foundation, Q4(a) (1 mark): Which term describes the allele for white flowers? (1) A heterozygous B homozygous C gamete D recessive
  6. June 2023, Biology Paper 1 Foundation, Q4(b)(i) (2 marks): Complete the Punnett square. (2) wrinkled seeds R round seeds r
  7. June 2023, Biology Paper 1 Foundation, Q4(b)(ii) (1 mark): State the percentage of the offspring that will produce round seeds. (1) percentage = %
  8. June 2023, Biology Paper 1 Foundation, Q4(c)(i) (2 marks): Calculate the ratio of offspring with purple flowers to offspring with white flowers. Give your answer to the nearest whole number. (2) ratio : 1
  9. June 2023, Biology Paper 1 Foundation, Q4(c)(ii) (2 marks): Explain why it was possible for this cross to produce some offspring with white flowers. (2)
  10. June 2023, Biology Paper 1 Foundation, Q5(a)(ii) (1 mark): The colour of an apple is an observable characteristic. Which is the term for an observable characteristic? (1) A gene B genotype C heterozygous D phenotype
  11. June 2022, Biology Paper 1 Foundation, Q3(c)(ii) (2 marks): Figure 6 shows the inheritance of cystic fibrosis in a family. F represents the dominant allele that does not cause cystic fibrosis. f represents the recessive
  12. June 2022, Biology Paper 1 Foundation, Q3(c)(iii) (1 mark): State the genotype of person C. (1)
  13. November 2021, Biology Paper 1 Higher, Q4(b)(ii) (3 marks): Haemochromatosis can be inherited. Haemochromatosis occurs when a person inherits two copies of a recessive allele. Figure 6 shows the inheritance of haemochrom
  14. November 2021, Biology Paper 1 Foundation, Q2(a)(i) (1 mark): Two parents are heterozygous for sickle cell disease. Complete the Punnett square to show the possible genotypes of their children. (1) D d D d
  15. November 2021, Biology Paper 1 Foundation, Q2(a)(ii) (1 mark): State the percentage probability that their children could have sickle cell disease. (1) percentage probability = %
  16. November 2021, Biology Paper 1 Foundation, Q2(a)(iii) (2 marks): A father with the genotype dd and a mother with the genotype DD plan to have several children. Explain why none of their children will have sickle cell disease.
  17. November 2021, Biology Paper 1 Foundation, Q3(a) (1 mark): Carrots have different physical characteristics such as colour. Which genetic term describes the physical characteristics of a carrot? (1) A genotype B monohybr
  18. June 2019, Biology Paper 1 Foundation, Q4(a)(ii) (1 mark): State the gender shown by this karyogram. (1)
  19. June 2019, Biology Paper 1 Foundation, Q4(a)(iii) (2 marks): Complete the Punnett square to show how gender is inherited. (2) male gametes female gametes
  20. June 2019, Biology Paper 1 Foundation, Q4(a)(iv) (1 mark): State the probability that a child will be male. (1)

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